Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2589107..2589672 Replicon chromosome
Accession NZ_CP054523
Organism Bifidobacterium longum subsp. infantis strain PI_005

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE64_RS11390 Protein ID WP_060620320.1
Coordinates 2589107..2589397 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE64_RS11395 Protein ID WP_032743427.1
Coordinates 2589394..2589672 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE64_RS11370 (HUE64_11395) 2584316..2584882 + 567 WP_032743433.1 DUF3566 domain-containing protein -
HUE64_RS11375 (HUE64_11400) 2585528..2586949 + 1422 WP_032743432.1 ATP-binding protein -
HUE64_RS11380 (HUE64_11405) 2587010..2587234 - 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE64_RS11385 (HUE64_11410) 2587383..2588729 - 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE64_RS11390 (HUE64_11415) 2589107..2589397 - 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE64_RS11395 (HUE64_11420) 2589394..2589672 - 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE64_RS11400 (HUE64_11425) 2590145..2590261 - 117 Protein_2220 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE64_RS11405 (HUE64_11430) 2590475..2591119 + 645 WP_032743426.1 hypothetical protein -
HUE64_RS11410 (HUE64_11435) 2591541..2591732 - 192 WP_032743423.1 hypothetical protein -
HUE64_RS11425 (HUE64_11450) 2593207..2594469 - 1263 WP_032743422.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2587010..2601152 14142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159833 WP_060620320.1 NZ_CP054523:c2589397-2589107 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159833 NZ_CP070152:c4781946-4781839 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159833 WP_032743427.1 NZ_CP054523:c2589672-2589394 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159833 NZ_CP070152:4781999-4782060 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References