Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1205722..1206287 Replicon chromosome
Accession NZ_CP054522
Organism Bifidobacterium longum subsp. infantis strain PI_007

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE66_RS05130 Protein ID WP_060620320.1
Coordinates 1205722..1206012 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE66_RS05135 Protein ID WP_032743427.1
Coordinates 1206009..1206287 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE66_RS05110 (HUE66_05120) 1200931..1201497 + 567 WP_032743433.1 DUF3566 domain-containing protein -
HUE66_RS05115 (HUE66_05125) 1202143..1203564 + 1422 WP_032743432.1 ATP-binding protein -
HUE66_RS05120 (HUE66_05130) 1203625..1203849 - 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE66_RS05125 (HUE66_05135) 1203998..1205344 - 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE66_RS05130 (HUE66_05140) 1205722..1206012 - 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE66_RS05135 (HUE66_05145) 1206009..1206287 - 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE66_RS11530 1206760..1206987 - 228 WP_212105774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE66_RS05145 (HUE66_05155) 1207090..1207734 + 645 WP_032743426.1 hypothetical protein -
HUE66_RS05150 (HUE66_05160) 1208156..1208347 - 192 WP_032743423.1 hypothetical protein -
HUE66_RS05165 (HUE66_05175) 1209822..1211084 - 1263 WP_032743422.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1203625..1217767 14142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159825 WP_060620320.1 NZ_CP054522:c1206012-1205722 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159825 NZ_CP070152:3223786-3224136 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159825 WP_032743427.1 NZ_CP054522:c1206287-1206009 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159825 NZ_CP070152:3223541-3223792 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References