Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1850220..1850803 Replicon chromosome
Accession NZ_CP054521
Organism Bifidobacterium longum subsp. infantis strain PI_008

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S2VZ23
Locus tag HUE67_RS08180 Protein ID WP_032745284.1
Coordinates 1850220..1850522 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag HUE67_RS08185 Protein ID WP_007057517.1
Coordinates 1850519..1850803 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE67_RS08165 (HUE67_08170) 1845959..1849078 - 3120 WP_136527129.1 alpha-mannosidase -
HUE67_RS08170 (HUE67_08175) 1849239..1849727 - 489 WP_032745281.1 D-aminoacyl-tRNA deacylase -
HUE67_RS08175 (HUE67_08180) 1849886..1850182 + 297 WP_032745282.1 hypothetical protein -
HUE67_RS08180 (HUE67_08185) 1850220..1850522 + 303 WP_032745284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUE67_RS08185 (HUE67_08190) 1850519..1850803 + 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
HUE67_RS08190 (HUE67_08195) 1850912..1851463 + 552 Protein_1593 IS30 family transposase -
HUE67_RS08195 (HUE67_08200) 1851481..1852212 - 732 WP_032744305.1 ABC transporter permease -
HUE67_RS08200 (HUE67_08205) 1852209..1853117 - 909 WP_032744304.1 ABC transporter ATP-binding protein -
HUE67_RS08205 (HUE67_08210) 1853215..1854297 - 1083 Protein_1596 transposase -
HUE67_RS08210 (HUE67_08215) 1854291..1854659 + 369 WP_155270629.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1851008..1851463 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-92)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11350.08 Da        Isoelectric Point: 10.4626

>T159821 WP_032745284.1 NZ_CP054521:1850220-1850522 [Bifidobacterium longum subsp. infantis]
IKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDKST
QQTDIRQAHDILNDYKEQRQ

Download         Length: 303 bp

>T159821 NZ_CP070152:1736915-1737289 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT159821 WP_007057517.1 NZ_CP054521:1850519-1850803 [Bifidobacterium longum subsp. infantis]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp

>AT159821 NZ_CP070152:1736457-1736825 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2VZ23

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References