Detailed information of TA system TA159817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 907255..907744
• Replicon: chromosome
• Accession: NZ_CP054521
• Organism: Bifidobacterium longum subsp. infantis strain PI_008

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE67_RS03835
• Protein ID: WP_229773994.1
• Coordinates: 907517..907744 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4V2N072
• Locus tag: HUE67_RS03830
• Protein ID: WP_032744823.1
• Coordinates: 907255..907491 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE67_RS03815 (HUE67_03820)	903409..904596	+	1188	WP_032744825.1	carboxylate--amine ligase	-
HUE67_RS03820 (HUE67_03825)	904623..905948	+	1326	WP_230581269.1	MFS transporter	-
HUE67_RS03825 (HUE67_03830)	905959..906672	+	714	WP_080714860.1	4'-phosphopantetheinyl transferase superfamily protein	-
HUE67_RS03830 (HUE67_03835)	907255..907491	+	237	WP_032744823.1	ribbon-helix-helix domain-containing protein	Antitoxin
HUE67_RS03835 (HUE67_03840)	907517..907744	+	228	WP_229773994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUE67_RS03840 (HUE67_03845)	908095..908757	-	663	WP_136527151.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
HUE67_RS03845 (HUE67_03850)	908778..909734	+	957	WP_032744820.1	A/G-specific adenine glycosylase	-
HUE67_RS03850 (HUE67_03855)	909799..910521	+	723	WP_032744819.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	899145..907744	8599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8653.22 Da
• Isoelectric Point: 10.1818

>T159817 WP_229773994.1 NZ_CP054521:907517-907744 [Bifidobacterium longum subsp. infantis]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Nucleotide

• Length: 228 bp

>T159817 NZ_CP070151:c10847-10569 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGACCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8928.15 Da
• Isoelectric Point: 4.2821

>AT159817 WP_032744823.1 NZ_CP054521:907255-907491 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT159817 NZ_CP070151:c11116-10847 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4V2N072