Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 264281..264846 Replicon chromosome
Accession NZ_CP054521
Organism Bifidobacterium longum subsp. infantis strain PI_008

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE67_RS01200 Protein ID WP_060620320.1
Coordinates 264556..264846 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE67_RS01195 Protein ID WP_032743427.1
Coordinates 264281..264559 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE67_RS01165 (HUE67_01165) 259484..260746 + 1263 WP_032743422.1 metallophosphoesterase -
HUE67_RS01180 (HUE67_01180) 262221..262412 + 192 WP_032743423.1 hypothetical protein -
HUE67_RS01185 (HUE67_01185) 262834..263478 - 645 WP_032743426.1 hypothetical protein -
HUE67_RS01190 (HUE67_01190) 263692..263808 + 117 Protein_228 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE67_RS01195 (HUE67_01195) 264281..264559 + 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE67_RS01200 (HUE67_01200) 264556..264846 + 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE67_RS01205 (HUE67_01205) 265224..266570 + 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE67_RS01210 (HUE67_01210) 266719..266943 + 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE67_RS01215 (HUE67_01215) 267004..268425 - 1422 WP_032743432.1 ATP-binding protein -
HUE67_RS01220 (HUE67_01220) 269071..269637 - 567 WP_032743433.1 DUF3566 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 254376..268425 14049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159816 WP_060620320.1 NZ_CP054521:264556-264846 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159816 NZ_CP070150:49800-50105 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159816 WP_032743427.1 NZ_CP054521:264281-264559 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159816 NZ_CP070150:49580-49798 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References