Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 2320529..2321382 Replicon chromosome
Accession NZ_CP054520
Organism Bifidobacterium longum subsp. infantis strain PI_009

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5BU34
Locus tag HUE68_RS10000 Protein ID WP_032745209.1
Coordinates 2320891..2321382 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag HUE68_RS09995 Protein ID WP_011068030.1
Coordinates 2320529..2320891 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE68_RS09990 (HUE68_10030) 2317684..2320383 + 2700 WP_032745210.1 aconitate hydratase AcnA -
HUE68_RS09995 (HUE68_10035) 2320529..2320891 + 363 WP_011068030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE68_RS10000 (HUE68_10040) 2320891..2321382 + 492 WP_032745209.1 PIN domain-containing protein Toxin
HUE68_RS10005 (HUE68_10045) 2321443..2323547 - 2105 Protein_1949 DUF262 domain-containing protein -
HUE68_RS10010 (HUE68_10050) 2323636..2324277 - 642 WP_032745208.1 GNAT family N-acetyltransferase -
HUE68_RS10015 (HUE68_10055) 2324318..2324458 - 141 Protein_1951 LuxR C-terminal-related transcriptional regulator -
HUE68_RS10020 (HUE68_10060) 2324627..2325529 + 903 WP_032745207.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18298.86 Da        Isoelectric Point: 4.5590

>T159815 WP_032745209.1 NZ_CP054520:2320891-2321382 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRRECKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCRTPAEIVA
ALE

Download         Length: 492 bp

>T159815 NZ_CP070149:13645-13950 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT159815 WP_011068030.1 NZ_CP054520:2320529-2320891 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp

>AT159815 NZ_CP070149:13425-13643 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D5BU34

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2W1N3

References