Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2109477..2110042 Replicon chromosome
Accession NZ_CP054519
Organism Bifidobacterium longum subsp. infantis strain PI_010

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE69_RS09200 Protein ID WP_060620320.1
Coordinates 2109477..2109767 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE69_RS09205 Protein ID WP_032743427.1
Coordinates 2109764..2110042 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE69_RS09180 (HUE69_09215) 2104686..2105252 + 567 WP_032743433.1 DUF3566 domain-containing protein -
HUE69_RS09185 (HUE69_09220) 2105898..2107319 + 1422 WP_032743432.1 ATP-binding protein -
HUE69_RS09190 (HUE69_09225) 2107380..2107604 - 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE69_RS09195 (HUE69_09230) 2107753..2109099 - 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE69_RS09200 (HUE69_09235) 2109477..2109767 - 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE69_RS09205 (HUE69_09240) 2109764..2110042 - 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE69_RS11590 2110515..2110742 - 228 WP_212105774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE69_RS09215 (HUE69_09250) 2110845..2111489 + 645 WP_032743426.1 hypothetical protein -
HUE69_RS09220 (HUE69_09255) 2111911..2112102 - 192 WP_032743423.1 hypothetical protein -
HUE69_RS09235 (HUE69_09270) 2113577..2114839 - 1263 WP_032743422.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2107380..2121522 14142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159809 WP_060620320.1 NZ_CP054519:c2109767-2109477 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159809 NZ_CP070148:c3623920-3623585 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159809 WP_032743427.1 NZ_CP054519:c2110042-2109764 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159809 NZ_CP070148:c3624168-3623920 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References