Detailed information of TA system TA159808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 1466580..1467069
• Replicon: chromosome
• Accession: NZ_CP054519
• Organism: Bifidobacterium longum subsp. infantis strain PI_010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE69_RS06575
• Protein ID: WP_229773994.1
• Coordinates: 1466580..1466807 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4V2N072
• Locus tag: HUE69_RS06580
• Protein ID: WP_032744823.1
• Coordinates: 1466833..1467069 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE69_RS06560 (HUE69_06580)	1463803..1464525	-	723	WP_032744819.1	hypothetical protein	-
HUE69_RS06565 (HUE69_06585)	1464590..1465546	-	957	WP_032744820.1	A/G-specific adenine glycosylase	-
HUE69_RS06570 (HUE69_06590)	1465567..1466229	+	663	WP_136527151.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
HUE69_RS06575 (HUE69_06595)	1466580..1466807	-	228	WP_229773994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUE69_RS06580 (HUE69_06600)	1466833..1467069	-	237	WP_032744823.1	ribbon-helix-helix domain-containing protein	Antitoxin
HUE69_RS06585 (HUE69_06605)	1467652..1468365	-	714	WP_080714860.1	4'-phosphopantetheinyl transferase superfamily protein	-
HUE69_RS06590 (HUE69_06610)	1468376..1469701	-	1326	WP_230581269.1	MFS transporter	-
HUE69_RS06595 (HUE69_06615)	1469728..1470915	-	1188	WP_032744825.1	carboxylate--amine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1466580..1475913	9333

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8653.22 Da
• Isoelectric Point: 10.1818

>T159808 WP_229773994.1 NZ_CP054519:c1466807-1466580 [Bifidobacterium longum subsp. infantis]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Nucleotide

• Length: 228 bp

>T159808 NZ_CP070148:c2784414-2784163 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8928.15 Da
• Isoelectric Point: 4.2821

>AT159808 WP_032744823.1 NZ_CP054519:c1467069-1466833 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT159808 NZ_CP070148:c2784166-2783912 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A4V2N072