Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/RelB(antitoxin) |
| Location | 1012206..1012845 | Replicon | chromosome |
| Accession | NZ_CP054519 | ||
| Organism | Bifidobacterium longum subsp. infantis strain PI_010 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | W6EZW1 |
| Locus tag | HUE69_RS04590 | Protein ID | WP_014484977.1 |
| Coordinates | 1012489..1012845 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | HUE69_RS04585 | Protein ID | WP_003829235.1 |
| Coordinates | 1012206..1012502 (+) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUE69_RS04560 (HUE69_04575) | 1007597..1010275 | - | 2679 | WP_032743694.1 | alanine--tRNA ligase | - |
| HUE69_RS04565 (HUE69_04580) | 1010404..1010640 | - | 237 | WP_007053386.1 | hypothetical protein | - |
| HUE69_RS04570 (HUE69_04585) | 1010640..1011038 | - | 399 | WP_032743693.1 | DUF948 domain-containing protein | - |
| HUE69_RS04575 (HUE69_04590) | 1011121..1011795 | - | 675 | WP_032743692.1 | histidine phosphatase family protein | - |
| HUE69_RS04580 (HUE69_04595) | 1011870..1012136 | + | 267 | WP_230581180.1 | hypothetical protein | - |
| HUE69_RS04585 (HUE69_04600) | 1012206..1012502 | + | 297 | WP_003829235.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HUE69_RS04590 (HUE69_04605) | 1012489..1012845 | + | 357 | WP_014484977.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| HUE69_RS04595 (HUE69_04610) | 1013120..1013722 | - | 603 | WP_032743691.1 | transglutaminase family protein | - |
| HUE69_RS04600 (HUE69_04615) | 1013827..1014060 | - | 234 | WP_235625961.1 | hypothetical protein | - |
| HUE69_RS04605 (HUE69_04620) | 1014077..1014466 | + | 390 | WP_230581178.1 | cytidine deaminase | - |
| HUE69_RS04610 (HUE69_04625) | 1014604..1015386 | + | 783 | WP_032743690.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| HUE69_RS04615 (HUE69_04630) | 1015565..1016191 | - | 627 | WP_007052130.1 | 30S ribosomal protein S4 | - |
| HUE69_RS04620 (HUE69_04635) | 1016390..1017382 | - | 993 | WP_080714690.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13302.25 Da Isoelectric Point: 8.9603
>T159806 WP_014484977.1 NZ_CP054519:1012489-1012845 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA
Download Length: 357 bp
>T159806 NZ_CP070148:2773718-2774092 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 99 a.a. Molecular weight: 10997.50 Da Isoelectric Point: 4.2896
>AT159806 WP_003829235.1 NZ_CP054519:1012206-1012502 [Bifidobacterium longum subsp. infantis]
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED
Download Length: 297 bp
>AT159806 NZ_CP070148:2773261-2773629 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|