Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 611729..612582 Replicon chromosome
Accession NZ_CP054519
Organism Bifidobacterium longum subsp. infantis strain PI_010

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5BU34
Locus tag HUE69_RS02570 Protein ID WP_032745209.1
Coordinates 612091..612582 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag HUE69_RS02565 Protein ID WP_011068030.1
Coordinates 611729..612091 (+) Length 121 a.a.

Genomic Context


HUE69_RS02560HUE69_RS02565HUE69_RS02570HUE69_RS02590HUE69_RS02575HUE69_RS02580HUE69_RS02585
Location: 608884..611583 (2700 bp)
Type: Others
Protein ID: WP_032745210.1
Location: 611729..612091 (363 bp)
Type: Antitoxin
Protein ID: WP_011068030.1
Location: 612091..612582 (492 bp)
Type: Toxin
Protein ID: WP_032745209.1
Location: 615827..616729 (903 bp)
Type: Others
Protein ID: WP_032745207.1
Location: 612643..614747 (2105 bp)
Type: Others
Protein ID: Protein_504
Location: 614836..615477 (642 bp)
Type: Others
Protein ID: WP_032745208.1
Location: 615518..615658 (141 bp)
Type: Others
Protein ID: Protein_506
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HUE69_RS02560 (HUE69_02585)608884..611583+2700WP_032745210.1aconitate hydratase AcnA-
HUE69_RS02565 (HUE69_02590)611729..612091+363WP_011068030.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HUE69_RS02570 (HUE69_02595)612091..612582+492WP_032745209.1PIN domain-containing proteinToxin
HUE69_RS02575 (HUE69_02600)612643..614747-2105Protein_504DUF262 domain-containing protein-
HUE69_RS02580 (HUE69_02605)614836..615477-642WP_032745208.1GNAT family N-acetyltransferase-
HUE69_RS02585 (HUE69_02610)615518..615658-141Protein_506LuxR C-terminal-related transcriptional regulator-
HUE69_RS02590 (HUE69_02615)615827..616729+903WP_032745207.1Bax inhibitor-1/YccA family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-141)

Antitoxin

(6-53)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 18298.86 Da        Isoelectric Point: 4.5590

>T159805 WP_032745209.1 NZ_CP054519:612091-612582 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRRECKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCRTPAEIVA
ALE

Download         Length: 492 bp

>T159805 NZ_CP070148:c2506181-2506079 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT159805 WP_011068030.1 NZ_CP054519:611729-612091 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp

>AT159805 NZ_CP070148:2506041-2506309 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7D5BU34


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1S2W1N3

References