Detailed information of TA system TA159801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 630869..631400
• Replicon: chromosome
• Accession: NZ_CP054492
• Organism: Candidatus Sulfurimonas baltica strain GD2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE88_RS03120
• Protein ID: WP_194372491.1
• Coordinates: 631113..631400 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HUE88_RS03115
• Protein ID: WP_194370971.1
• Coordinates: 630869..631123 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE88_RS03095	626700..627821	+	1122	WP_194370963.1	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-
HUE88_RS03100	627823..628683	+	861	WP_194370965.1	SDR family oxidoreductase	-
HUE88_RS03105	628690..629901	+	1212	WP_194370967.1	glycosyltransferase family 4 protein	-
HUE88_RS03110	629898..630806	+	909	WP_194370969.1	NAD-dependent epimerase/dehydratase family protein	-
HUE88_RS03115	630869..631123	+	255	WP_194370971.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HUE88_RS03120	631113..631400	+	288	WP_194372491.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUE88_RS03125	631397..632359	+	963	WP_194370972.1	glycosyltransferase family 4 protein	-
HUE88_RS03130	632415..632648	+	234	WP_194370974.1	hypothetical protein	-
HUE88_RS03135	632641..633066	+	426	WP_194370976.1	PIN domain-containing protein	-
HUE88_RS03140	633145..633429	+	285	WP_194370978.1	nucleotidyltransferase domain-containing protein	-
HUE88_RS03145	633426..633857	+	432	WP_194370980.1	hypothetical protein	-
HUE88_RS03150	633877..635625	+	1749	WP_194372493.1	UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)	-
HUE88_RS03155	635688..636002	+	315	WP_194370983.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-57)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11415.29 Da
• Isoelectric Point: 10.1669

>T159801 WP_194372491.1 NZ_CP054492:631113-631400 [Candidatus Sulfurimonas baltica]
MTYKLKFIKESNKEWNKLTSTIKEQFQKKLKERLENPKVPKDKLNGYENIYKIKLRSVGYRLAYEVKDDEIVVLVLSVGK
RENNAIYYNLKDRVE

Nucleotide

• Length: 288 bp

>T159801 NZ_CP070148:1684467-1684841 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9549.84 Da
• Isoelectric Point: 4.0414

>AT159801 WP_194370971.1 NZ_CP054492:630869-631123 [Candidatus Sulfurimonas baltica]
MQPILANYTASITELKKSPTQLLKDAGNEAVAILNHNVASAYLVPSELYEKMMDIIDDYYLAKEVEDRLSYKEEDLIEVN
INDL

Nucleotide

• Length: 255 bp

>AT159801 NZ_CP070148:1684043-1684420 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCACCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA