Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1868998..1869765 Replicon chromosome
Accession NZ_CP054482
Organism Macrococcus bohemicus strain 19Msa422

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag HT586_RS09705 Protein ID WP_165958672.1
Coordinates 1868998..1869141 (-) Length 48 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag HT586_RS09710 Protein ID WP_111744515.1
Coordinates 1869154..1869765 (-) Length 204 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT586_RS09695 1865939..1867471 - 1533 WP_096075980.1 exopolyphosphatase -
HT586_RS09700 1867502..1868887 - 1386 WP_096075979.1 class II fumarate hydratase -
HT586_RS09705 1868998..1869141 - 144 WP_165958672.1 hypothetical protein Toxin
HT586_RS09710 1869154..1869765 - 612 WP_111744515.1 glucosamine-6-phosphate isomerase Antitoxin
HT586_RS09715 1870096..1870833 - 738 WP_188018706.1 oxygen-insensitive NADPH nitroreductase -
HT586_RS09720 1870846..1871319 - 474 WP_096075976.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HT586_RS09725 1871320..1872444 - 1125 WP_203545697.1 tRNA epoxyqueuosine(34) reductase QueG -
HT586_RS09730 1872595..1873317 - 723 WP_203545698.1 amino acid ABC transporter ATP-binding protein -
HT586_RS09735 1873310..1874716 - 1407 WP_096078059.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5413.64 Da        Isoelectric Point: 3.6118

>T159799 WP_165958672.1 NZ_CP054482:c1869141-1868998 [Macrococcus bohemicus]
MSTSHDNKNEMVTDFDDVVELGKEMEQISEQNAEAREEGQEQEDDPQ

Download         Length: 144 bp

>T159799 NZ_CP070148:c1075825-1075607 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 204 a.a.        Molecular weight: 22526.48 Da        Isoelectric Point: 5.1301

>AT159799 WP_111744515.1 NZ_CP054482:c1869765-1869154 [Macrococcus bohemicus]
MAMNFKIFEDKLTVSNYVADLFRKQMSNNPTSIIATALGDEAGHVIAELKADIARNPVETSQIHIFDYDKLRGDYGTVGI
VDKQYHEATGKDIMELIKDEAKTKENKGKLTTLFATITQDGSVGYKEINQDNDKGLRSAREIIIVLTGADKASIVEKLYN
TEAGGNFEAANLKTHRMVNVILDDAAAAGLPQDIREYYFQKFA

Download         Length: 612 bp

>AT159799 NZ_CP070148:c1076225-1075851 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References