Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2567194..2567828 Replicon chromosome
Accession NZ_CP054477
Organism Treponema denticola strain OMZ 823

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N80_RS12090 Protein ID WP_253699420.1
Coordinates 2567194..2567598 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N80_RS12095 Protein ID WP_253682979.1
Coordinates 2567598..2567828 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N80_RS12070 (E4N80_12030) 2563660..2564775 + 1116 WP_253699416.1 diguanylate cyclase DgcA -
E4N80_RS12075 (E4N80_12035) 2564797..2565426 + 630 WP_253699417.1 rhomboid family intramembrane serine protease -
E4N80_RS12080 (E4N80_12040) 2565447..2566127 + 681 WP_253699418.1 hypothetical protein -
E4N80_RS12085 (E4N80_12045) 2566131..2567144 + 1014 WP_253699419.1 tRNA-dihydrouridine synthase family protein -
E4N80_RS12090 (E4N80_12050) 2567194..2567598 - 405 WP_253699420.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N80_RS12095 (E4N80_12055) 2567598..2567828 - 231 WP_253682979.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N80_RS12100 (E4N80_12060) 2568108..2569670 - 1563 WP_253699421.1 LTA synthase family protein -
E4N80_RS12105 (E4N80_12065) 2569692..2570891 - 1200 WP_253699422.1 coenzyme F420-0:L-glutamate ligase -
E4N80_RS12110 (E4N80_12070) 2571019..2572353 + 1335 WP_253699423.1 DUF1015 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15523.89 Da        Isoelectric Point: 6.9280

>T159796 WP_253699420.1 NZ_CP054477:c2567598-2567194 [Treponema denticola]
MYLLDTNICIFLIKNKNPYLKKKIFNCKKEELFLSSITIAELEYGVSKSQFREKNRHALLDFCSDFTNIIDFTTEDTETY
GMIRAYLENKGIPIGPFDTQIAAQALARNLTVVTNNIREFSRIPGLKVDDWTKE

Download         Length: 405 bp

>T159796 NZ_CP070148:421620-421997 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8755.95 Da        Isoelectric Point: 4.7660

>AT159796 WP_253682979.1 NZ_CP054477:c2567828-2567598 [Treponema denticola]
MICTKVFTSGNSQAVRIPKEFHIDFSELLIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPAMQEREVF

Download         Length: 231 bp

>AT159796 NZ_CP070148:421162-421530 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References