Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2520754..2521379 Replicon chromosome
Accession NZ_CP054477
Organism Treponema denticola strain OMZ 823

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N80_RS11880 Protein ID WP_253699383.1
Coordinates 2520754..2521149 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N80_RS11885 Protein ID WP_253699384.1
Coordinates 2521149..2521379 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N80_RS11855 2516223..2516582 + 360 WP_253699378.1 hypothetical protein -
E4N80_RS11860 (E4N80_11825) 2516630..2517466 + 837 WP_253699379.1 FAD-dependent thymidylate synthase -
E4N80_RS11865 (E4N80_11830) 2517478..2519202 + 1725 WP_253699380.1 TrkH family potassium uptake protein -
E4N80_RS11870 (E4N80_11835) 2519217..2519909 + 693 WP_253699381.1 TrkA family potassium uptake protein -
E4N80_RS11875 (E4N80_11840) 2519920..2520672 + 753 WP_253699382.1 hypothetical protein -
E4N80_RS11880 (E4N80_11845) 2520754..2521149 - 396 WP_253699383.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N80_RS11885 (E4N80_11850) 2521149..2521379 - 231 WP_253699384.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N80_RS11890 (E4N80_11855) 2521480..2521917 + 438 WP_253699385.1 ABC transporter ATP-binding protein -
E4N80_RS11895 (E4N80_11860) 2522014..2523606 - 1593 WP_253683101.1 ABC transporter ATP-binding protein -
E4N80_RS11900 (E4N80_11865) 2523853..2524233 + 381 WP_253681125.1 DUF2089 domain-containing protein -
E4N80_RS11905 (E4N80_11870) 2524279..2524593 + 315 WP_253699386.1 hypothetical protein -
E4N80_RS11910 (E4N80_11875) 2524661..2525680 + 1020 WP_253699387.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15177.75 Da        Isoelectric Point: 9.6268

>T159795 WP_253699383.1 NZ_CP054477:c2521149-2520754 [Treponema denticola]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSRYIERNRISLIKFLTPFSVLNFDDRDAEEFG
KIRTTLKNEGKIIGAYDMLIAAQALAKNLILVTDNTKEFCRIKNLTIEDWK

Download         Length: 396 bp

>T159795 NZ_CP070148:151295-151468 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8841.98 Da        Isoelectric Point: 6.3367

>AT159795 WP_253699384.1 NZ_CP054477:c2521379-2521149 [Treponema denticola]
METAKLFQNGRSQAVRLPKKYNFSGTEVFIRRAGESVILFPKNKEWETFLEGLNGFTDDFMEEGRNQPELQDRKGL

Download         Length: 231 bp

>AT159795 NZ_CP070148:150971-151267 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References