Detailed information of TA system TA159792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2022982..2023547
• Replicon: chromosome
• Accession: NZ_CP054477
• Organism: Treponema denticola strain OMZ 823

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: M2BU34
• Locus tag: E4N80_RS09485
• Protein ID: WP_010694033.1
• Coordinates: 2023209..2023547 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: E4N80_RS09480
• Protein ID: WP_253699002.1
• Coordinates: 2022982..2023215 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N80_RS09460 (E4N80_09435)	2018882..2021257	+	2376	WP_253698998.1	endopeptidase La	-
E4N80_RS09465 (E4N80_09440)	2021341..2021568	+	228	WP_253698999.1	DUF2281 domain-containing protein	-
E4N80_RS09470 (E4N80_09445)	2021565..2021792	+	228	WP_253699000.1	PIN domain-containing protein	-
E4N80_RS09475 (E4N80_09450)	2021842..2022507	+	666	WP_253699001.1	hypothetical protein	-
E4N80_RS09480 (E4N80_09455)	2022982..2023215	+	234	WP_253699002.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E4N80_RS09485 (E4N80_09460)	2023209..2023547	+	339	WP_010694033.1	endoribonuclease MazF	Toxin
E4N80_RS09490 (E4N80_09465)	2023650..2024474	+	825	WP_253699003.1	hypothetical protein	-
E4N80_RS09495 (E4N80_09470)	2024471..2025031	+	561	WP_253699004.1	hypothetical protein	-
E4N80_RS09500 (E4N80_09475)	2025083..2026126	+	1044	WP_253699005.1	DMT family transporter	-
E4N80_RS09505 (E4N80_09480)	2026254..2027069	+	816	WP_253699006.1	protein-ADP-ribose hydrolase	-
E4N80_RS09510 (E4N80_09485)	2027087..2027956	+	870	WP_253699007.1	Sir2 silent information regulator family NAD-dependent deacetylase	-
E4N80_RS09515 (E4N80_09490)	2027965..2028384	+	420	WP_253699008.1	Rrf2 family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• Antitoxin PemI-like (1-77)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12821.66 Da
• Isoelectric Point: 6.6952

>T159792 WP_010694033.1 NZ_CP054477:2023209-2023547 [Treponema denticola]
MVNSNYVPDRGDLVWLDFNPQAGHEQKGRRPAICISQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVK
NLDYKKRSCDFIEKTTEEEINAVVDNIKLLIE

Nucleotide

• Length: 339 bp

>T159792 NZ_CP070144:c2787185-2786844 [Klebsiella oxytoca]
ATGTGGAATGTTGAAACAACGGAGGTTTTCGACAAGTGGTTTGAGGCGCAGACCGAAGCACTCAAAGAGGATATGCTCGC
CGCTATGGTGATCTTATCCGAGTATGGCCCCCAACTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCTTTTTCGA
ATATGAAAGAGTTACGCGTTCAGCATCAAGGTAGCCCGATCCGCGCTTTCTTTGTATTTGATCCTTCTCGTCGTGGCATC
CTGTTATGTGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8624.85 Da
• Isoelectric Point: 5.6423

>AT159792 WP_253699002.1 NZ_CP054477:2022982-2023215 [Treponema denticola]
MQVVVQKWGNSLGFRIPSLWAKDNNVKHGSKIEVIAEKGKIVILPQEKNLDDMLAMVTSENVHSEISTGYSVGNEEW

Nucleotide

• Length: 234 bp

>AT159792 NZ_CP070144:c2786834-2786535 [Klebsiella oxytoca]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAAGCGATGCG
TCAGGTTATCGCTTTAAGTATGTTAAGGGAGGAGCTGAATTTGTCTCAGGCCGAGCTGGCTAAGGCTATGGGTGTTAAAC
AGCCCACCATTGCTAAAATGGAGCAGGCCGATAACGACCCCCGCCTGTCAACGCTGAAGCGGTACGTTGCGGCGCTCGGG
GGTGAGTTAAGTATTGATGTTAAGCTGCCAGGCGGCAAGCGAATCGCATTCCATCTTTAA

Structures

Toxin

• AlphaFold DB: M2BU34