Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1253974..1254593 Replicon chromosome
Accession NZ_CP054477
Organism Treponema denticola strain OMZ 823

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4N80_RS05855 Protein ID WP_253700940.1
Coordinates 1253974..1254282 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E4N80_RS05860 Protein ID WP_253700941.1
Coordinates 1254279..1254593 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N80_RS05825 (E4N80_05800) 1249339..1250091 - 753 WP_253700934.1 ABC transporter ATP-binding protein -
E4N80_RS05830 (E4N80_05805) 1250674..1250973 - 300 WP_253700935.1 HigA family addiction module antitoxin -
E4N80_RS05835 (E4N80_05810) 1250987..1251268 - 282 WP_253700936.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4N80_RS05840 (E4N80_05815) 1251481..1251924 + 444 WP_253700937.1 hypothetical protein -
E4N80_RS05845 (E4N80_05820) 1251946..1252485 + 540 WP_253700938.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
E4N80_RS05850 (E4N80_05825) 1252636..1253919 + 1284 WP_253700939.1 family 1 glycosylhydrolase -
E4N80_RS05855 (E4N80_05830) 1253974..1254282 + 309 WP_253700940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N80_RS05860 (E4N80_05835) 1254279..1254593 + 315 WP_253700941.1 putative addiction module antidote protein Antitoxin
E4N80_RS05865 (E4N80_05840) 1254630..1255571 - 942 WP_253700942.1 DMT family transporter -
E4N80_RS05870 (E4N80_05845) 1255601..1256743 - 1143 WP_253700943.1 hypothetical protein -
E4N80_RS05875 (E4N80_05850) 1256808..1258214 - 1407 WP_253700944.1 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB -
E4N80_RS05880 (E4N80_05855) 1258218..1258859 - 642 WP_253700945.1 tetratricopeptide repeat protein -
E4N80_RS05885 (E4N80_05860) 1258849..1259226 - 378 WP_253700946.1 polymer-forming cytoskeletal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(2-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12018.08 Da        Isoelectric Point: 10.3056

>T159790 WP_253700940.1 NZ_CP054477:1253974-1254282 [Treponema denticola]
MRTIKKTEVFDTWLSKLKDEKGKAKITDRIMRLKRGNKGDHRIIDKDIYELRIHFGPDYRIYCTDKNNEIILLLIAGDKS
TQPKDIKKAQQMIKLLEQGDTK

Download         Length: 309 bp

>T159790 NZ_CP070144:c1416403-1416146 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11790.35 Da        Isoelectric Point: 5.1199

>AT159790 WP_253700941.1 NZ_CP054477:1254279-1254593 [Treponema denticola]
MKITDFDPADYLNTKEAMIEYLNEALKTSIEDNTPEHFTEALGDITRAQGFTNVAKHTDLNREHLYRSLSKKGNPTFSTI
LKLLNFLGLEINIIDPQTAKPAYC

Download         Length: 315 bp

>AT159790 NZ_CP070144:c1416135-1415584 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGACCTGGTTGCCGATTTGCTCAACGATGAAAGTGCTCACCCGAGATTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCCCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References