Detailed information of TA system TA159789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1236689..1237254
• Replicon: chromosome
• Accession: NZ_CP054477
• Organism: Treponema denticola strain OMZ 823

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: M2BU34
• Locus tag: E4N80_RS05740
• Protein ID: WP_010694033.1
• Coordinates: 1236689..1237027 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: E4N80_RS05745
• Protein ID: WP_253700918.1
• Coordinates: 1237021..1237254 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N80_RS05715 (E4N80_05685)	1231917..1233227	-	1311	Protein_1115	TIGR04141 family sporadically distributed protein	-
E4N80_RS05720 (E4N80_05695)	1233242..1233490	-	249	WP_253700914.1	hypothetical protein	-
E4N80_RS05725 (E4N80_05700)	1234278..1234751	-	474	WP_253700915.1	GNAT family N-acetyltransferase	-
E4N80_RS05730 (E4N80_05705)	1234956..1235603	-	648	WP_253700916.1	Vat family streptogramin A O-acetyltransferase	-
E4N80_RS05735 (E4N80_05710)	1235818..1236588	-	771	WP_253700917.1	HAD family hydrolase	-
E4N80_RS05740 (E4N80_05715)	1236689..1237027	-	339	WP_010694033.1	endoribonuclease MazF	Toxin
E4N80_RS05745 (E4N80_05720)	1237021..1237254	-	234	WP_253700918.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E4N80_RS05750 (E4N80_05725)	1237882..1238091	-	210	WP_253700919.1	BrnA antitoxin family protein	-
E4N80_RS05755 (E4N80_05730)	1238195..1238353	-	159	WP_253700920.1	hypothetical protein	-
E4N80_RS05760 (E4N80_05735)	1238415..1238720	-	306	WP_253700921.1	hypothetical protein	-
E4N80_RS05765 (E4N80_05740)	1238723..1239019	-	297	WP_253700922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E4N80_RS05770 (E4N80_05745)	1239427..1239696	+	270	WP_253700923.1	hypothetical protein	-
E4N80_RS05775 (E4N80_05750)	1239765..1240439	-	675	WP_253700924.1	adenylate/guanylate cyclase domain-containing protein	-
E4N80_RS05780 (E4N80_05755)	1240457..1240984	-	528	WP_253700925.1	DUF5706 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1197823..1240439	42616

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• SpoVT-AbrB domain (6-45)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12821.66 Da
• Isoelectric Point: 6.6952

>T159789 WP_010694033.1 NZ_CP054477:c1237027-1236689 [Treponema denticola]
MVNSNYVPDRGDLVWLDFNPQAGHEQKGRRPAICISQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVK
NLDYKKRSCDFIEKTTEEEINAVVDNIKLLIE

Nucleotide

• Length: 339 bp

>T159789 NZ_CP070144:1180858-1181076 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8589.80 Da
• Isoelectric Point: 4.7023

>AT159789 WP_253700918.1 NZ_CP054477:c1237254-1237021 [Treponema denticola]
MQVVVQKWGNSLGFRIPSLWAKDNNVKNGSKIEVIAEKGKIVILPQEKTLDDMLAMVTSENVHSEISTGYSVGDEEW

Nucleotide

• Length: 234 bp

>AT159789 NZ_CP070144:1180457-1180831 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCAGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA

Structures

Toxin

• AlphaFold DB: M2BU34