Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 924765..925371 Replicon chromosome
Accession NZ_CP054476
Organism Methyloligella sp. GL2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HT051_RS04335 Protein ID WP_174540895.1
Coordinates 924765..924959 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HT051_RS04340 Protein ID WP_174540896.1
Coordinates 924979..925371 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT051_RS04325 921980..923797 - 1818 WP_174540893.1 DNA polymerase Y family protein -
HT051_RS04330 923706..924503 - 798 WP_174540894.1 hypothetical protein -
HT051_RS04335 924765..924959 + 195 WP_174540895.1 type II toxin-antitoxin system HicA family toxin Toxin
HT051_RS04340 924979..925371 + 393 WP_174540896.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HT051_RS04345 925507..926091 + 585 WP_174540897.1 L,D-transpeptidase -
HT051_RS04350 926286..926852 + 567 WP_174540898.1 type 1 glutamine amidotransferase -
HT051_RS04355 927125..927757 + 633 WP_174540899.1 peroxiredoxin -
HT051_RS04360 927914..928072 + 159 WP_174540900.1 hypothetical protein -
HT051_RS04365 928192..928578 + 387 WP_208454382.1 NUDIX domain-containing protein -
HT051_RS04370 928781..929779 + 999 WP_174540902.1 ferrochelatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-120)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7100.31 Da        Isoelectric Point: 11.0240

>T159788 WP_174540895.1 NZ_CP054476:924765-924959 [Methyloligella sp. GL2]
MPLSSKQIIRALETDGWYRVGQTGSHIHFKHANKQGKLTVPHPVKDLPIGTLKSIEKASGVKLR

Download         Length: 195 bp

>T159788 NZ_CP070136:c14628-14281 [Escherichia coli]
ATGTGGACGGTACTTTTTAGCCAGCGATTTGACGACTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGC
TGATTTGAAAAATCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTAAAAGGTTCTCGGTACAAAA
ATATGAAAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGCCGGGCTATC
GTTCTTTGTGCAGGAGACAAAAGTAACGATAAGCGGTTTTATAAAAAACTGGTGCGTATAGCTGAGGATGAGTTTGCAGC
ACATCTGAACACACTGGAGAGCAAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13535.32 Da        Isoelectric Point: 4.4335

>AT159788 WP_174540896.1 NZ_CP054476:924979-925371 [Methyloligella sp. GL2]
MAKLFYPAILEKGDNTYGVSFPNLPGCVSAGSTAEEALVNAHEALAGHVALMVQDGDPLPKPSPVDAVVADPEINLVAVS
LVGVTLPGRAKRVNVTLDEALLDEIDAASENRSRFLSDAARAELARRSAG

Download         Length: 393 bp

>AT159788 NZ_CP070136:c14281-13982 [Escherichia coli]
ATGAGAACATTAGATGAGGTGATTGCCAGCCGTTCACCTGAAAGCCAGGCGCGAATTAAAGAAATGGCAGATGAGATGAT
TCTTGAGGTCGGCTTGCAGATGATGCGTGAAGAACTCCAGTTATCACAAAAACAGGTTGCTGAGGCGATGGGTATTAGTC
AGCCAGCAGTAACAAAGCTGGAGCAGCGCGGAAATGATTTAAAGCTGGCGACATTAAAGCGTTACGTTGAAGCTATGGGA
GGCAAATTAAGCCTGGATGTTGAGCTTCCCACAGGAAAACGAATAGCGTTTAACATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References