Detailed information of TA system TA159787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3632545..3634118
• Replicon: chromosome
• Accession: NZ_CP054475
• Organism: Thalassolituus hydrocarbonoclasticus strain alknpb1M-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HUF19_RS16320
• Protein ID: WP_260997586.1
• Coordinates: 3632820..3634118 (+)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HUF19_RS16315
• Protein ID: WP_260997585.1
• Coordinates: 3632545..3632820 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUF19_RS16305 (HUF19_16240)	3628377..3628889	-	513	WP_260997583.1	lipocalin family protein	-
HUF19_RS16310 (HUF19_16245)	3629039..3631687	-	2649	WP_260997584.1	molybdopterin-dependent oxidoreductase	-
HUF19_RS16315 (HUF19_16250)	3632545..3632820	+	276	WP_260997585.1	helix-turn-helix domain-containing protein	Antitoxin
HUF19_RS16320 (HUF19_16255)	3632820..3634118	+	1299	WP_260997586.1	type II toxin-antitoxin system HipA family toxin	Toxin
HUF19_RS16325 (HUF19_16260)	3634585..3636240	-	1656	WP_260997587.1	acetolactate synthase large subunit	-
HUF19_RS16330 (HUF19_16265)	3636506..3638116	-	1611	WP_260997588.1	FAD-dependent oxidoreductase	-
HUF19_RS16335 (HUF19_16270)	3638226..3638516	+	291	WP_260997589.1	hypothetical protein	-
HUF19_RS16340 (HUF19_16275)	3638590..3638994	+	405	WP_145468036.1	ribonucleotide reductase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48776.08 Da
• Isoelectric Point: 7.0674

>T159787 WP_260997586.1 NZ_CP054475:3632820-3634118 [Thalassolituus hydrocarbonoclasticus]
MADLTVAMNGIEVGRLSMDASGAMSFRYLDSWSERPGARAISLSLPLKRDIFAGERVFNFFDNLLPDSDAIRARMQARFS
ASSSHPFNLLAAVGRDCIGAIQLYPEYETMPDVQQLTSAPLSEGQIAAMLRSYQRAPLGMEADTDFRISLAGAQEKTALL
WHNQKWQLPIGSTPTSHILKLPIGFLEPRNIDLRQSNHNEWLCLEILKAYGIDVAKAQLASFEDQNVLITERFDRRWSKD
DRWLMRLPQEDFCQALGVSPALKYENHGGPGIKESMELLRGSQQAIHDRETFFKLQILFWMLAAIDGHAKNFSLFIEPES
AFRMTPIYDVLSAYPLMRANSLPAAKAKMAMSVKGKSRHYHWQRIEPRHFMSTAKAVGFSVQRAQQLLMELAESAAAVIS
RVEMLLPHDFPPVIADSIFKGLQERADFIREV

Nucleotide

• Length: 1299 bp

>T159787 NZ_CP070134:c5092455-5092348 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9962.06 Da
• Isoelectric Point: 5.7929

>AT159787 WP_260997585.1 NZ_CP054475:3632545-3632820 [Thalassolituus hydrocarbonoclasticus]
MKITSPRGLADALQQARKQQNQTQQAIGELAGTKQSTVSAFETSPEHARVETLFKLLSALNLELVLEPRRQAPASGSANS
QASDQAWDQEW

Nucleotide

• Length: 276 bp

>AT159787 NZ_CP070134:5092508-5092569 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT