159783

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3465361..3466582 Replicon chromosome
Accession NZ_CP054473
Organism Pseudomonas aeruginosa strain PAAK095

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MS095_RS16345 Protein ID WP_003114949.1
Coordinates 3465361..3465939 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MS095_RS16350 Protein ID WP_003088112.1
Coordinates 3466028..3466582 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS095_RS16330 3460637..3461915 + 1279 Protein_3226 TolC family protein -
MS095_RS16335 3461905..3464076 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
MS095_RS16340 3464066..3465253 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MS095_RS16345 3465361..3465939 - 579 WP_003114949.1 HD domain-containing protein Toxin
MS095_RS16350 3466028..3466582 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
MS095_RS16355 3466740..3468935 - 2196 WP_023082959.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MS095_RS16360 3468940..3469401 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
MS095_RS16365 3469732..3470055 + 324 WP_003102734.1 multidrug efflux SMR transporter -
MS095_RS16370 3470068..3470466 + 399 WP_174543473.1 NADH-quinone oxidoreductase subunit A -
MS095_RS16375 3470463..3471014 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T159783 WP_003114949.1 NZ_CP054473:c3465939-3465361 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T159783 NZ_CP070134:c4149727-4149509 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT159783 WP_003088112.1 NZ_CP054473:c3466582-3466028 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT159783 NZ_CP070134:c4150127-4149753 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References