159776

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2697253..2698048 Replicon chromosome
Accession NZ_CP054472
Organism Pseudomonas aeruginosa strain PAAK088

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MS088_RS12790 Protein ID WP_019486655.1
Coordinates 2697869..2698048 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MS088_RS12785 Protein ID WP_021263386.1
Coordinates 2697253..2697828 (-) Length 192 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS088_RS12750 2692939..2693118 + 180 WP_015648950.1 Cro/Cl family transcriptional regulator -
MS088_RS12755 2693151..2693534 + 384 WP_015648949.1 hypothetical protein -
MS088_RS12760 2693702..2694274 + 573 WP_023096627.1 hypothetical protein -
MS088_RS12765 2694277..2695287 + 1011 WP_034061664.1 hypothetical protein -
MS088_RS12770 2695415..2695828 + 414 WP_034061691.1 hypothetical protein -
MS088_RS12775 2695821..2696264 + 444 WP_019396730.1 RusA family crossover junction endodeoxyribonuclease -
MS088_RS12780 2696293..2697162 + 870 WP_034061667.1 hypothetical protein -
MS088_RS12785 2697253..2697828 - 576 WP_021263386.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MS088_RS12790 2697869..2698048 - 180 WP_019486655.1 type II toxin-antitoxin system HicA family toxin Toxin
MS088_RS12795 2698508..2698843 + 336 WP_003119044.1 phage holin, lambda family -
MS088_RS12800 2698840..2699457 + 618 WP_034058608.1 glycoside hydrolase family 19 protein -
MS088_RS12805 2699475..2699906 + 432 WP_170958635.1 hypothetical protein -
MS088_RS12810 2700003..2700740 + 738 WP_034061674.1 hypothetical protein -
MS088_RS12815 2700955..2701500 + 546 WP_031627904.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2672405..2722065 49660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6605.65 Da        Isoelectric Point: 11.1475

>T159776 WP_019486655.1 NZ_CP054472:c2698048-2697869 [Pseudomonas aeruginosa]
MKFSEFRRWLRAQGVTFEAGKGSHFKVTAPNGKTTTFADHGAKEMPEPTRKAIIKQLGL

Download         Length: 180 bp

>T159776 NZ_CP070134:3256312-3256485 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 192 a.a.        Molecular weight: 21294.78 Da        Isoelectric Point: 8.3556

>AT159776 WP_021263386.1 NZ_CP054472:c2697828-2697253 [Pseudomonas aeruginosa]
MYNFAIRFEQDDSAPGVAVFCRDLPELNSYGDTVEHALSEAVDAIETTLSLYVDQRRSIPVASAPEPEEHVVHLPAVTVA
KIALWNEMMRRGMRKADLCRVLGIAQVQGDRLVDFLHTSKMEQVESALAALEMRLVICAEPVKQPKQCKGAGCIRDRRLV
KARRLLRARLLELTESSGAFTRAPKIKKPGI

Download         Length: 576 bp

>AT159776 NZ_CP070134:3255988-3256284 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References