159774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 145808..146313 Replicon chromosome
Accession NZ_CP054472
Organism Pseudomonas aeruginosa strain PAAK088

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag MS088_RS00680 Protein ID WP_003083773.1
Coordinates 145808..146089 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag MS088_RS00685 Protein ID WP_003112628.1
Coordinates 146086..146313 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS088_RS00655 141059..142408 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
MS088_RS00660 142457..143143 + 687 WP_004351997.1 FadR family transcriptional regulator -
MS088_RS00665 143244..143978 + 735 WP_003117208.1 GntR family transcriptional regulator -
MS088_RS00670 144182..144568 + 387 WP_014602345.1 aegerolysin family protein -
MS088_RS00675 144600..145508 - 909 WP_003083769.1 LysR family transcriptional regulator -
MS088_RS00680 145808..146089 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
MS088_RS00685 146086..146313 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
MS088_RS00690 146488..147108 - 621 WP_009314940.1 hypothetical protein -
MS088_RS00695 147216..147716 + 501 WP_003112629.1 LEA type 2 family protein -
MS088_RS00700 147789..148130 + 342 WP_003101229.1 alkylphosphonate utilization protein -
MS088_RS00705 148212..149639 - 1428 WP_003083784.1 GABA permease -
MS088_RS00710 149808..151301 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T159774 WP_003083773.1 NZ_CP054472:c146089-145808 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T159774 NZ_CP070134:c2548769-2548662 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT159774 WP_003112628.1 NZ_CP054472:c146313-146086 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT159774 NZ_CP070134:2548827-2548881 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References