Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3081986..3082570 Replicon chromosome
Accession NZ_CP054469
Organism Burkholderia gladioli strain CGB10

Toxin (Protein)


Gene name relE Uniprot ID A0A833V778
Locus tag HUB32_RS32410 Protein ID WP_017918439.1
Coordinates 3082274..3082570 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A560UNM0
Locus tag HUB32_RS32405 Protein ID WP_036030606.1
Coordinates 3081986..3082270 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUB32_RS32385 3077084..3078367 - 1284 WP_186288914.1 4-aminobutyrate--2-oxoglutarate transaminase -
HUB32_RS32390 3078503..3080140 + 1638 WP_186288915.1 PLP-dependent aminotransferase family protein -
HUB32_RS32395 3080278..3081453 + 1176 WP_046582019.1 ABC transporter substrate-binding protein -
HUB32_RS32400 3081602..3081928 + 327 WP_036054555.1 hypothetical protein -
HUB32_RS32405 3081986..3082270 - 285 WP_036030606.1 putative addiction module antidote protein Antitoxin
HUB32_RS32410 3082274..3082570 - 297 WP_017918439.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUB32_RS32415 3082694..3083632 - 939 WP_046582023.1 ketopantoate reductase family protein -
HUB32_RS32420 3083789..3084259 + 471 WP_013689305.1 Lrp/AsnC family transcriptional regulator -
HUB32_RS32425 3084303..3085139 - 837 WP_036054549.1 DMT family transporter -
HUB32_RS32430 3085358..3086419 + 1062 WP_105827369.1 selenide, water dikinase SelD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(11-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11303.14 Da        Isoelectric Point: 10.4966

>T159771 WP_017918439.1 NZ_CP054469:c3082570-3082274 [Burkholderia gladioli]
MVTLLRSSEFTNWLSSLRDQRGKARIAARLISAQLGNFGEYRVIGEGVREMKVDFGPSYRIYYVRRAEIVYVLLCGGDKS
TQKKDIKRALQMARELKE

Download         Length: 297 bp

>T159771 NZ_CP070134:2139915-2140379 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10072.47 Da        Isoelectric Point: 5.0484

>AT159771 WP_036030606.1 NZ_CP054469:c3082270-3081986 [Burkholderia gladioli]
MPDYAEFDAADYLDNDETVAEFLAVAAEDPDPAVFLAAVAAVARARGMTKVASEAGLGRVTLHKALTPGAHPRYETVQKI
LRSLGLRMTFTVAH

Download         Length: 285 bp

>AT159771 NZ_CP070134:2139580-2139915 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A833V778

Antitoxin

Source ID Structure
AlphaFold DB A0A560UNM0

References