Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1546776..1547582 Replicon chromosome
Accession NZ_CP054444
Organism Staphylococcus saprophyticus strain UTI-056

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag HSZ51_RS07745 Protein ID WP_011302805.1
Coordinates 1547397..1547582 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q49YQ1
Locus tag HSZ51_RS07740 Protein ID WP_011302804.1
Coordinates 1546776..1547375 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ51_RS07720 1542654..1544117 + 1464 WP_047502301.1 ABC transporter substrate-binding protein/permease -
HSZ51_RS07725 1544110..1544832 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
HSZ51_RS07730 1544993..1546120 + 1128 WP_047502298.1 tRNA epoxyqueuosine(34) reductase QueG -
HSZ51_RS07735 1546125..1546595 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HSZ51_RS07740 1546776..1547375 + 600 WP_011302804.1 glucosamine-6-phosphate isomerase Antitoxin
HSZ51_RS07745 1547397..1547582 + 186 WP_011302805.1 hypothetical protein Toxin
HSZ51_RS07750 1547739..1548155 + 417 WP_011302806.1 hypothetical protein -
HSZ51_RS07755 1548533..1549918 + 1386 WP_011302807.1 class II fumarate hydratase -
HSZ51_RS07760 1550121..1550948 - 828 WP_011302808.1 RluA family pseudouridine synthase -
HSZ51_RS07765 1551133..1552248 + 1116 WP_011302809.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T159760 WP_011302805.1 NZ_CP054444:1547397-1547582 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T159760 NZ_CP070134:129060-129755 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACTATTCAGGCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCG
CAGGAATACACATCAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATT
TATCCGCGACATTTTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGC
CAGAATGATTCCGGCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTG
AAACCAATGTGTTGAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22279.11 Da        Isoelectric Point: 4.8524

>AT159760 WP_011302804.1 NZ_CP054444:1546776-1547375 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSAREVILIITGSDKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT159760 NZ_CP070134:128794-129060 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB Q49YQ1

References