Detailed information of TA system TA159759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1407748..1408277
• Replicon: chromosome
• Accession: NZ_CP054444
• Organism: Staphylococcus saprophyticus strain UTI-056

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HSZ51_RS06915
• Protein ID: WP_002482752.1
• Coordinates: 1407915..1408277 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A380HJK7
• Locus tag: HSZ51_RS06910
• Protein ID: WP_037538046.1
• Coordinates: 1407748..1407918 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ51_RS06885	1403479..1403958	+	480	WP_011302698.1	PH domain-containing protein	-
HSZ51_RS06890	1403951..1405489	+	1539	WP_047503187.1	PH domain-containing protein	-
HSZ51_RS06895	1405482..1405982	+	501	WP_061050524.1	PH domain-containing protein	-
HSZ51_RS06900	1406046..1406396	+	351	WP_002482750.1	holo-ACP synthase	-
HSZ51_RS06905	1406512..1407660	+	1149	WP_061050525.1	alanine racemase	-
HSZ51_RS06910	1407748..1407918	+	171	WP_037538046.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HSZ51_RS06915	1407915..1408277	+	363	WP_002482752.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HSZ51_RS06920	1408614..1409615	+	1002	WP_041080774.1	PP2C family protein-serine/threonine phosphatase	-
HSZ51_RS06925	1409694..1410020	+	327	WP_011302705.1	anti-sigma factor antagonist	-
HSZ51_RS06930	1410022..1410504	+	483	WP_002482755.1	anti-sigma B factor RsbW	-
HSZ51_RS06935	1410479..1411249	+	771	WP_002482756.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13498.70 Da
• Isoelectric Point: 10.3173

>T159759 WP_002482752.1 NZ_CP054444:1407915-1408277 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKS

Nucleotide

• Length: 363 bp

>T159759 NZ_CP070134:c38148-37999 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6304.97 Da
• Isoelectric Point: 4.0121

>AT159759 WP_037538046.1 NZ_CP054444:1407748-1407918 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Nucleotide

• Length: 171 bp

>AT159759 NZ_CP070134:37777-37955 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Antitoxin

• AlphaFold DB: A0A380HJK7