159758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1396077..1396591 Replicon chromosome
Accession NZ_CP054444
Organism Staphylococcus saprophyticus strain UTI-056

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag HSZ51_RS06855 Protein ID WP_002482741.1
Coordinates 1396385..1396591 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag HSZ51_RS06850 Protein ID WP_002482740.1
Coordinates 1396077..1396370 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ51_RS06825 1391239..1392030 + 792 WP_047503196.1 hydroxyethylthiazole kinase -
HSZ51_RS06830 1392030..1392668 + 639 WP_011302689.1 thiamine phosphate synthase -
HSZ51_RS06835 1392756..1393625 + 870 WP_011302690.1 membrane protein insertase YidC -
HSZ51_RS06840 1393707..1394315 - 609 WP_172969239.1 HD domain-containing protein -
HSZ51_RS06845 1394450..1395934 - 1485 WP_011302692.1 cardiolipin synthase -
HSZ51_RS06850 1396077..1396370 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
HSZ51_RS06855 1396385..1396591 + 207 WP_002482741.1 hypothetical protein Toxin
HSZ51_RS06860 1396805..1396945 + 141 WP_002482742.1 hypothetical protein -
HSZ51_RS06865 1397238..1398443 - 1206 WP_011302694.1 rod shape-determining protein RodA -
HSZ51_RS06870 1398692..1399762 + 1071 WP_061050523.1 D-alanine--D-alanine ligase -
HSZ51_RS06875 1399775..1401130 + 1356 WP_047503189.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T159758 WP_002482741.1 NZ_CP054444:1396385-1396591 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T159758 NZ_CP070133:91118-91267 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT159758 WP_002482740.1 NZ_CP054444:1396077-1396370 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT159758 NZ_CP070133:c91074-91013 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References