159748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1003160..1003966 Replicon chromosome
Accession NZ_CP054440
Organism Staphylococcus saprophyticus strain UTI-058y

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag HSZ52_RS05015 Protein ID WP_011302805.1
Coordinates 1003781..1003966 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q49YQ1
Locus tag HSZ52_RS05010 Protein ID WP_011302804.1
Coordinates 1003160..1003759 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ52_RS04990 999038..1000501 + 1464 WP_047502301.1 ABC transporter substrate-binding protein/permease -
HSZ52_RS04995 1000494..1001216 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
HSZ52_RS05000 1001377..1002504 + 1128 WP_047502298.1 tRNA epoxyqueuosine(34) reductase QueG -
HSZ52_RS05005 1002509..1002979 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HSZ52_RS05010 1003160..1003759 + 600 WP_011302804.1 glucosamine-6-phosphate isomerase Antitoxin
HSZ52_RS05015 1003781..1003966 + 186 WP_011302805.1 hypothetical protein Toxin
HSZ52_RS05020 1004123..1004539 + 417 WP_011302806.1 hypothetical protein -
HSZ52_RS05025 1004917..1006302 + 1386 WP_011302807.1 class II fumarate hydratase -
HSZ52_RS05030 1006504..1007331 - 828 WP_011302808.1 RluA family pseudouridine synthase -
HSZ52_RS05035 1007516..1008631 + 1116 WP_011302809.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T159748 WP_011302805.1 NZ_CP054440:1003781-1003966 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T159748 NZ_CP070124:3108309-3108411 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22279.11 Da        Isoelectric Point: 4.8524

>AT159748 WP_011302804.1 NZ_CP054440:1003160-1003759 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSAREVILIITGSDKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT159748 NZ_CP070124:c3108449-3108181 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB Q49YQ1

References