Detailed information of TA system TA159747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 850111..850640
• Replicon: chromosome
• Accession: NZ_CP054440
• Organism: Staphylococcus saprophyticus strain UTI-058y

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HSZ52_RS04090
• Protein ID: WP_002482752.1
• Coordinates: 850278..850640 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A380HJK7
• Locus tag: HSZ52_RS04085
• Protein ID: WP_037538046.1
• Coordinates: 850111..850281 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ52_RS04060	845842..846321	+	480	WP_011302698.1	PH domain-containing protein	-
HSZ52_RS04065	846314..847852	+	1539	WP_174543142.1	PH domain-containing protein	-
HSZ52_RS04070	847845..848345	+	501	WP_061050524.1	PH domain-containing protein	-
HSZ52_RS04075	848409..848759	+	351	WP_002482750.1	holo-ACP synthase	-
HSZ52_RS04080	848875..850023	+	1149	WP_061050525.1	alanine racemase	-
HSZ52_RS04085	850111..850281	+	171	WP_037538046.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HSZ52_RS04090	850278..850640	+	363	WP_002482752.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HSZ52_RS04095	850977..851978	+	1002	WP_041080774.1	PP2C family protein-serine/threonine phosphatase	-
HSZ52_RS04100	852057..852383	+	327	WP_011302705.1	anti-sigma factor antagonist	-
HSZ52_RS04105	852385..852867	+	483	WP_002482755.1	anti-sigma B factor RsbW	-
HSZ52_RS04110	852842..853612	+	771	WP_002482756.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13498.70 Da
• Isoelectric Point: 10.3173

>T159747 WP_002482752.1 NZ_CP054440:850278-850640 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKS

Nucleotide

• Length: 363 bp

>T159747 NZ_CP070124:c2824121-2823747 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6304.97 Da
• Isoelectric Point: 4.0121

>AT159747 WP_037538046.1 NZ_CP054440:850111-850281 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Nucleotide

• Length: 171 bp

>AT159747 NZ_CP070124:c2824578-2824210 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A380HJK7