Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 838440..838954 Replicon chromosome
Accession NZ_CP054440
Organism Staphylococcus saprophyticus strain UTI-058y

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag HSZ52_RS04030 Protein ID WP_002482741.1
Coordinates 838748..838954 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag HSZ52_RS04025 Protein ID WP_002482740.1
Coordinates 838440..838733 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ52_RS04000 833602..834393 + 792 WP_047503196.1 hydroxyethylthiazole kinase -
HSZ52_RS04005 834393..835031 + 639 WP_011302689.1 thiamine phosphate synthase -
HSZ52_RS04010 835119..835988 + 870 WP_011302690.1 membrane protein insertase YidC -
HSZ52_RS04015 836070..836678 - 609 WP_172969239.1 HD domain-containing protein -
HSZ52_RS04020 836813..838297 - 1485 WP_011302692.1 cardiolipin synthase -
HSZ52_RS04025 838440..838733 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
HSZ52_RS04030 838748..838954 + 207 WP_002482741.1 hypothetical protein Toxin
HSZ52_RS04035 839168..839308 + 141 WP_002482742.1 hypothetical protein -
HSZ52_RS04040 839601..840806 - 1206 WP_011302694.1 rod shape-determining protein RodA -
HSZ52_RS04045 841055..842125 + 1071 WP_061050523.1 D-alanine--D-alanine ligase -
HSZ52_RS04050 842138..843493 + 1356 WP_047503189.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T159746 WP_002482741.1 NZ_CP054440:838748-838954 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T159746 NZ_CP070124:2813672-2813926 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT159746 WP_002482740.1 NZ_CP054440:838440-838733 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT159746 NZ_CP070124:2813424-2813675 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References