Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1080080..1080886 Replicon chromosome
Accession NZ_CP054438
Organism Staphylococcus saprophyticus strain UTI-042y

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag HSZ49_RS05320 Protein ID WP_011302805.1
Coordinates 1080701..1080886 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A380HJZ2
Locus tag HSZ49_RS05315 Protein ID WP_002482876.1
Coordinates 1080080..1080679 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ49_RS05295 1075958..1077421 + 1464 WP_174543875.1 ABC transporter substrate-binding protein/permease -
HSZ49_RS05300 1077414..1078136 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
HSZ49_RS05305 1078297..1079424 + 1128 WP_002482874.1 tRNA epoxyqueuosine(34) reductase QueG -
HSZ49_RS05310 1079429..1079899 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HSZ49_RS05315 1080080..1080679 + 600 WP_002482876.1 glucosamine-6-phosphate isomerase Antitoxin
HSZ49_RS05320 1080701..1080886 + 186 WP_011302805.1 hypothetical protein Toxin
HSZ49_RS05325 1081043..1081459 + 417 WP_011302806.1 hypothetical protein -
HSZ49_RS05330 1081837..1083222 + 1386 WP_174543876.1 class II fumarate hydratase -
HSZ49_RS05335 1083425..1084252 - 828 WP_115338456.1 RluA family pseudouridine synthase -
HSZ49_RS05340 1084437..1085552 + 1116 WP_002482881.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T159745 WP_011302805.1 NZ_CP054438:1080701-1080886 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T159745 NZ_CP070124:2813424-2813675 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22294.12 Da        Isoelectric Point: 4.9719

>AT159745 WP_002482876.1 NZ_CP054438:1080080-1080679 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSSREVILIITGSNKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT159745 NZ_CP070124:2813672-2813926 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJZ2

References