Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 941518..942047 Replicon chromosome
Accession NZ_CP054438
Organism Staphylococcus saprophyticus strain UTI-042y

Toxin (Protein)


Gene name mazF Uniprot ID A0A7Y8QER5
Locus tag HSZ49_RS04505 Protein ID WP_041080775.1
Coordinates 941685..942047 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A380HJK7
Locus tag HSZ49_RS04500 Protein ID WP_037538046.1
Coordinates 941518..941688 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ49_RS04475 937249..937728 + 480 WP_174543853.1 PH domain-containing protein -
HSZ49_RS04480 937721..939259 + 1539 WP_002482748.1 PH domain-containing protein -
HSZ49_RS04485 939252..939752 + 501 WP_041080777.1 PH domain-containing protein -
HSZ49_RS04490 939816..940166 + 351 WP_002482750.1 holo-ACP synthase -
HSZ49_RS04495 940282..941430 + 1149 WP_174543854.1 alanine racemase -
HSZ49_RS04500 941518..941688 + 171 WP_037538046.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HSZ49_RS04505 941685..942047 + 363 WP_041080775.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HSZ49_RS04510 942384..943385 + 1002 WP_041080774.1 PP2C family protein-serine/threonine phosphatase -
HSZ49_RS04515 943464..943790 + 327 WP_011302705.1 anti-sigma factor antagonist -
HSZ49_RS04520 943792..944274 + 483 WP_002482755.1 anti-sigma B factor RsbW -
HSZ49_RS04525 944249..945019 + 771 WP_041080773.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.70 Da        Isoelectric Point: 10.3173

>T159744 WP_041080775.1 NZ_CP054438:941685-942047 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHNIRSHKS

Download         Length: 363 bp

>T159744 NZ_CP070124:2018007-2018342 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6304.97 Da        Isoelectric Point: 4.0121

>AT159744 WP_037538046.1 NZ_CP054438:941518-941688 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT159744 NZ_CP070124:2017759-2018007 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8QER5

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJK7

References