Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 929849..930363 Replicon chromosome
Accession NZ_CP054438
Organism Staphylococcus saprophyticus strain UTI-042y

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag HSZ49_RS04445 Protein ID WP_002482741.1
Coordinates 930157..930363 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag HSZ49_RS04440 Protein ID WP_002482740.1
Coordinates 929849..930142 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ49_RS04415 925011..925802 + 792 WP_174543851.1 hydroxyethylthiazole kinase -
HSZ49_RS04420 925802..926440 + 639 WP_002482736.1 thiamine phosphate synthase -
HSZ49_RS04425 926528..927397 + 870 WP_002482737.1 membrane protein insertase YidC -
HSZ49_RS04430 927479..928126 - 648 WP_174544265.1 HD domain-containing protein -
HSZ49_RS04435 928222..929706 - 1485 WP_011302692.1 cardiolipin synthase -
HSZ49_RS04440 929849..930142 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
HSZ49_RS04445 930157..930363 + 207 WP_002482741.1 hypothetical protein Toxin
HSZ49_RS04450 930576..930716 + 141 WP_002482742.1 hypothetical protein -
HSZ49_RS04455 931009..932214 - 1206 WP_174543852.1 rod shape-determining protein RodA -
HSZ49_RS04460 932463..933533 + 1071 WP_002482744.1 D-alanine--D-alanine ligase -
HSZ49_RS04465 933546..934901 + 1356 WP_002482745.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T159743 WP_002482741.1 NZ_CP054438:930157-930363 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T159743 NZ_CP070124:1864217-1864624 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT159743 WP_002482740.1 NZ_CP054438:929849-930142 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT159743 NZ_CP070124:1863970-1864236 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References