Detailed information of TA system TA159735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 877820..878349
• Replicon: chromosome
• Accession: NZ_CP054434
• Organism: Staphylococcus saprophyticus strain UTI-035

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HSZ47_RS04195
• Protein ID: WP_002482752.1
• Coordinates: 877987..878349 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A380HJK7
• Locus tag: HSZ47_RS04190
• Protein ID: WP_037538046.1
• Coordinates: 877820..877990 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ47_RS04165	873551..874030	+	480	WP_011302698.1	PH domain-containing protein	-
HSZ47_RS04170	874023..875561	+	1539	WP_047503187.1	PH domain-containing protein	-
HSZ47_RS04175	875554..876054	+	501	WP_061050524.1	PH domain-containing protein	-
HSZ47_RS04180	876118..876468	+	351	WP_002482750.1	holo-ACP synthase	-
HSZ47_RS04185	876584..877732	+	1149	WP_061050525.1	alanine racemase	-
HSZ47_RS04190	877820..877990	+	171	WP_037538046.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HSZ47_RS04195	877987..878349	+	363	WP_002482752.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HSZ47_RS04200	878686..879687	+	1002	WP_041080774.1	PP2C family protein-serine/threonine phosphatase	-
HSZ47_RS04205	879766..880092	+	327	WP_011302705.1	anti-sigma factor antagonist	-
HSZ47_RS04210	880094..880576	+	483	WP_002482755.1	anti-sigma B factor RsbW	-
HSZ47_RS04215	880551..881321	+	771	WP_002482756.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13498.70 Da
• Isoelectric Point: 10.3173

>T159735 WP_002482752.1 NZ_CP054434:877987-878349 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKS

Nucleotide

• Length: 363 bp

>T159735 NZ_CP070124:c82099-81722 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6304.97 Da
• Isoelectric Point: 4.0121

>AT159735 WP_037538046.1 NZ_CP054434:877820-877990 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Nucleotide

• Length: 171 bp

>AT159735 NZ_CP070124:c82556-82188 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTTTTTATCCAACATCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380HJK7