Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 866149..866663 Replicon chromosome
Accession NZ_CP054434
Organism Staphylococcus saprophyticus strain UTI-035

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag HSZ47_RS04135 Protein ID WP_002482741.1
Coordinates 866457..866663 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag HSZ47_RS04130 Protein ID WP_002482740.1
Coordinates 866149..866442 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ47_RS04105 861311..862102 + 792 WP_047503196.1 hydroxyethylthiazole kinase -
HSZ47_RS04110 862102..862740 + 639 WP_011302689.1 thiamine phosphate synthase -
HSZ47_RS04115 862828..863697 + 870 WP_011302690.1 membrane protein insertase YidC -
HSZ47_RS04120 863779..864387 - 609 WP_172969239.1 HD domain-containing protein -
HSZ47_RS04125 864522..866006 - 1485 WP_011302692.1 cardiolipin synthase -
HSZ47_RS04130 866149..866442 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
HSZ47_RS04135 866457..866663 + 207 WP_002482741.1 hypothetical protein Toxin
HSZ47_RS04140 866877..867017 + 141 WP_002482742.1 hypothetical protein -
HSZ47_RS04145 867310..868515 - 1206 WP_011302694.1 rod shape-determining protein RodA -
HSZ47_RS04150 868764..869834 + 1071 WP_061050523.1 D-alanine--D-alanine ligase -
HSZ47_RS04155 869847..871202 + 1356 WP_047503189.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T159734 WP_002482741.1 NZ_CP054434:866457-866663 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T159734 NZ_CP070124:c12348-12061 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT159734 WP_002482740.1 NZ_CP054434:866149-866442 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT159734 NZ_CP070124:c12074-11772 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References