Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1876079..1876669 Replicon chromosome
Accession NZ_CP054424
Organism Rhodoferax sp. BAB1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HTY51_RS08970 Protein ID WP_174252420.1
Coordinates 1876370..1876669 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HTY51_RS08965 Protein ID WP_174252419.1
Coordinates 1876079..1876366 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTY51_RS08935 1871529..1872098 + 570 WP_174252413.1 CDP-alcohol phosphatidyltransferase family protein -
HTY51_RS08940 1872095..1872592 + 498 WP_174252414.1 CDP-archaeol synthase -
HTY51_RS08945 1872704..1873408 + 705 WP_174252415.1 glutathione S-transferase N-terminal domain-containing protein -
HTY51_RS08950 1873422..1873892 + 471 WP_174252416.1 RidA family protein -
HTY51_RS08955 1873926..1875050 - 1125 WP_174252417.1 SMP-30/gluconolactonase/LRE family protein -
HTY51_RS08960 1875123..1876055 - 933 WP_174252418.1 histone deacetylase family protein -
HTY51_RS08965 1876079..1876366 - 288 WP_174252419.1 putative addiction module antidote protein Antitoxin
HTY51_RS08970 1876370..1876669 - 300 WP_174252420.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HTY51_RS08975 1877045..1877269 - 225 WP_174252421.1 hypothetical protein -
HTY51_RS08980 1877540..1877770 + 231 WP_174252422.1 hypothetical protein -
HTY51_RS08985 1877873..1878232 - 360 WP_174252423.1 hypothetical protein -
HTY51_RS08990 1878398..1879834 - 1437 WP_174252424.1 sensor histidine kinase -
HTY51_RS08995 1879831..1880511 - 681 WP_174252425.1 response regulator transcription factor -
HTY51_RS09000 1880511..1880819 - 309 WP_174252426.1 PepSY domain-containing protein -
HTY51_RS09005 1880986..1881378 + 393 WP_174254221.1 DUF1924 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-96)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11244.89 Da        Isoelectric Point: 10.0602

>T159733 WP_174252420.1 NZ_CP054424:c1876669-1876370 [Rhodoferax sp. BAB1]
VNTFLRTEEFDAWLSAMKDKVGRARIALRIRSAEHGNFGDCEPVGEGVSEMRVHAGPGYRVYYTRRGKVVYLLLLGGDKS
SQKRDIKRAIEMARTLDKE

Download         Length: 300 bp

>T159733 NZ_CP070119:c2814-1774 [Escherichia coli]
ATGGCACAGAACCCGTTTAAAGCACTAAATATCAATATTGACAAGATTGAGTCTGCTCTGACGCAGAATGGCGTCACAAA
CTATTCCTCTAATGTAAAAAACGAAAGAGAAACTCACATATCTGGCACATATAAAGGAATAGACTTCTTAATAAAACTAA
TGCCATCAGGCGGAAATACCACTATCGGAAGAGCGTCTGGGCAAAATAACACTTACTTTGATGAAATCGCCTTGATTATA
AAAGAAAACTGTTTGTATTCAGACACAAAGAACTTTGAATACACCATTCCAAAATTCAGTGATGATGACAGGGCAAATCT
ATTTGAATTTCTTTCTGAAGAGGGGATAACAATAACAGAAGATAATAATAACGATCCTAATTGTAAACACCAATATATTA
TGACCACCAGCAATGGTGACAGGGTCAGGGCAAAAATTTACAAGCGCGGCTCTATTCAATTCCAAGGAAAATACCTTCAA
ATCGCGAGTTTGATTAACGATTTCATGTGCTCAATACTAAACATGAAAGAGATTGTCGAACAAAAAAATAAAGAATTTAA
TGTTGACATAAAAAAAGAAACTATTGAGTCCGAGTTGCATAGCAAACTACCAAAAAGCATCGATAAAATCCATGAAGATA
TCAAAAAACAGCTATCATGCTCGCTAATAATGAAAAAAATAGATGTCGAAATGGAAGATTACTCAACATACTGCTTCTCT
GCATTAAGAGCCATAGAAGGCTTTATATATCAAATACTTAATGATGTTTGCAATCCATCATCATCAAAGAACCTTGGCGA
ATACTTCACTGAAAACAAACCCAAATATATAATCAGAGAAATACACCGAGAAACTATAAATGGTGAAATAGCGGAAGTTT
TGTGTGAATGCTACACTTACTGGCATGAGAACAGGCATGGTTTGTTTCATATGAAACCAGGAATAGCTGACACGAAGACA
ATTAACAAATTAGAATCAATCGCAATCATCGATACCGTTTGCCAATTAATAGATGGTGGCGTAGCTAGGTTGAAATTATG
A

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10208.76 Da        Isoelectric Point: 4.7639

>AT159733 WP_174252419.1 NZ_CP054424:c1876366-1876079 [Rhodoferax sp. BAB1]
MARLAPFDAADYLDDEETIAEYLTAALEDPNPDVLLAAVRDVARVRGMAQLAMDAGLGRESLYKALAPGAKPRYDTMLKL
LHALGVKLSATPVHS

Download         Length: 288 bp

>AT159733 NZ_CP070119:c1777-1397 [Escherichia coli]
ATGAAAAAAGATAAAAAATATCAAATAGAAGCAATAAAAAATAAAGATAAAACTTTATTTATTGTCTATGCTACTGATAT
TTATAGCCCGAGCGAATTTTTCTCAAAAATCGAATCCGACTTGAAGAAAAAGAAAAGCAAGGGTGATGTTTTTTTTGATT
TAATAATTCCTAACGGTGGAAAAAAAGATCGTTACGTCTATACGTCATTTAATGGCGAGAAGTTTTCAAGTTACACATTA
AACAAAGTTACGAAAACTGATGAATATAATGATTTATCTGAGCTCTCGGCTTCGTTCTTTAAAAAAAACTTTGATAAGAT
CAACGTAAACCTTCTATCCAAAGCCACATCATTTGCTTTGAAAAAAGGCATTCCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References