159731

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2309..2897 Replicon plasmid unnamed1
Accession NZ_CP054417
Organism Acinetobacter baumannii strain AB79

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag HTY63_RS19770 Protein ID WP_000438827.1
Coordinates 2309..2596 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag HTY63_RS19775 Protein ID WP_001983304.1
Coordinates 2583..2897 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTY63_RS19755 (HTY63_19670) 1..936 + 936 WP_001292329.1 replication initiation protein RepM -
HTY63_RS19760 (HTY63_19675) 1014..1532 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
HTY63_RS19765 (HTY63_19680) 1742..2041 + 300 WP_000358348.1 hypothetical protein -
HTY63_RS19770 (HTY63_19685) 2309..2596 + 288 WP_000438827.1 BrnT family toxin Toxin
HTY63_RS19775 (HTY63_19690) 2583..2897 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
HTY63_RS19780 (HTY63_19695) 3025..5436 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
HTY63_RS19785 (HTY63_19700) 5741..6202 + 462 WP_000761346.1 DIP1984 family protein -
HTY63_RS19790 (HTY63_19705) 6528..6737 - 210 WP_000069474.1 hypothetical protein -
HTY63_RS19795 (HTY63_19710) 6730..7032 - 303 WP_001129974.1 XRE family transcriptional regulator -
HTY63_RS19800 (HTY63_19715) 7025..7381 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11194 11194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T159731 WP_000438827.1 NZ_CP054417:2309-2596 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T159731 NZ_CP070117:c3747-3397 [Escherichia coli]
ATGTGGACTGTTTATTTTGGCAGATTATTTGATGAATGGTTTGAAGAGCAGGAACTAGCCCTAAAACGAAAAGTGCTGGC
TGAACTTAAACATCTTGAAGAGTTTGGCCCCTCTCTTTCACGGCCACATGCAGATACAGTGAAAGGGTCACGTCATAAGA
ATATGAAGGAACTACGTATACAATATGAGGGACACCCAATCAGGGCATTCTTTGCATTTGATCCAATTAGACAAGCAATC
ATTCTTTGCGCTGGCGACAAAAGTAATGATAAGAAATTTTACGACAGAATGATTCGTATTGCTGACGAAGAATTTTCCAC
TCACTTAGCCGAACTGGAGGGCAAAAAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT159731 WP_001983304.1 NZ_CP054417:2583-2897 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT159731 NZ_CP070117:c3400-3101 [Escherichia coli]
ATGAGAACATTAGAAGAAGTAATTGCGGCTCAATCACCTGAAAGTCAGGCGATCATCAAAGCTATGGCTGATGAGATGAT
TCTGGAAACAGGGCTGCAAATGATGCGTGAAGAATTGCAGCTTTCACAAAAACAGGTTGCTGATGCAATGGGAATCAGTC
AGCCCGCTGTAACTCAACTGGAACAGCGCGGAAATGATTTGAAGCTGGCAACGTTAAAGCGTTACGTTGAAGCTATGGGA
GGAAAGTTGAGCCTAGATGTTGAACTCCCTACCGGAAAGCGAGTGGCCTTTAACATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References