Detailed information of TA system TA159730

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 450400..451053
• Replicon: chromosome
• Accession: NZ_CP054416
• Organism: Acinetobacter baumannii strain AB79

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HTY63_RS02190
• Protein ID: WP_000607077.1
• Coordinates: 450664..451053 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: HTY63_RS02185
• Protein ID: WP_001288210.1
• Coordinates: 450400..450657 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HTY63_RS02165 (HTY63_02160)	445916..446923	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HTY63_RS02170 (HTY63_02165)	446942..447319	+	378	WP_001216380.1	50S ribosomal protein L17	-
HTY63_RS02175 (HTY63_02170)	447501..448991	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
HTY63_RS02180 (HTY63_02175)	449040..450212	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
HTY63_RS02185 (HTY63_02180)	450400..450657	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
HTY63_RS02190 (HTY63_02185)	450664..451053	+	390	WP_000607077.1	membrane protein	Toxin
HTY63_RS02195 (HTY63_02190)	451823..452908	+	1086	WP_000049106.1	hypothetical protein	-
HTY63_RS02200 (HTY63_02195)	452986..453552	+	567	WP_000651538.1	rhombosortase	-
HTY63_RS02205 (HTY63_02200)	453740..455935	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T159730 WP_000607077.1 NZ_CP054416:450664-451053 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T159730 NZ_CP070116:105099-105377 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT159730 WP_001288210.1 NZ_CP054416:450400-450657 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT159730 NZ_CP070116:104830-105099 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7