Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1103722..1104342 Replicon chromosome
Accession NZ_CP054411
Organism Enterobacter hormaechei strain KCJ3K19

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FCG87_RS05140 Protein ID WP_015571250.1
Coordinates 1103722..1103940 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FCG87_RS05145 Protein ID WP_006809850.1
Coordinates 1103968..1104342 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCG87_RS05110 (FCG87_005105) 1099734..1099994 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FCG87_RS05115 (FCG87_005110) 1099997..1100137 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FCG87_RS05120 (FCG87_005115) 1100134..1100844 - 711 WP_047654115.1 GNAT family protein -
FCG87_RS05125 (FCG87_005120) 1100946..1102406 + 1461 WP_047654114.1 PLP-dependent aminotransferase family protein -
FCG87_RS05130 (FCG87_005125) 1102378..1102845 - 468 WP_022650495.1 YlaC family protein -
FCG87_RS05135 (FCG87_005130) 1102962..1103513 - 552 WP_022650496.1 maltose O-acetyltransferase -
FCG87_RS05140 (FCG87_005135) 1103722..1103940 - 219 WP_015571250.1 HHA domain-containing protein Toxin
FCG87_RS05145 (FCG87_005140) 1103968..1104342 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FCG87_RS05150 (FCG87_005145) 1104853..1107999 - 3147 WP_137048069.1 multidrug efflux RND transporter permease subunit AcrB -
FCG87_RS05155 (FCG87_005150) 1108022..1109215 - 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T159708 WP_015571250.1 NZ_CP054411:c1103940-1103722 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T159708 NZ_CP070113:7411-7716 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT159708 WP_006809850.1 NZ_CP054411:c1104342-1103968 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT159708 NZ_CP070113:7191-7409 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References