Detailed information of TA system TA159707

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 568303..568978
• Replicon: chromosome
• Accession: NZ_CP054411
• Organism: Enterobacter hormaechei strain KCJ3K19

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FCG87_RS02730
• Protein ID: WP_137048537.1
• Coordinates: 568658..568978 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FCG87_RS02725
• Protein ID: WP_137048535.1
• Coordinates: 568303..568626 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCG87_RS02695 (FCG87_002685)	563949..564389	+	441	WP_137048524.1	hypothetical protein	-
FCG87_RS02700 (FCG87_002690)	564425..564787	+	363	WP_137048527.1	hypothetical protein	-
FCG87_RS02705 (FCG87_002695)	565134..566426	+	1293	WP_137048529.1	hypothetical protein	-
FCG87_RS02710 (FCG87_002700)	566730..567548	+	819	WP_170970043.1	DUF932 domain-containing protein	-
FCG87_RS02715 (FCG87_002705)	567581..568051	+	471	WP_137048533.1	DNA repair protein RadC	-
FCG87_RS02720 (FCG87_002710)	568060..568281	+	222	WP_032642916.1	DUF987 domain-containing protein	-
FCG87_RS02725 (FCG87_002715)	568303..568626	+	324	WP_137048535.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FCG87_RS02730 (FCG87_002720)	568658..568978	+	321	WP_137048537.1	TA system toxin CbtA family protein	Toxin
FCG87_RS02735 (FCG87_002725)	569092..569922	+	831	WP_137048540.1	DUF4942 domain-containing protein	-
FCG87_RS02740 (FCG87_002730)	569999..571006	+	1008	WP_137048544.1	restriction endonuclease	-
FCG87_RS02745 (FCG87_002735)	571190..572056	-	867	WP_059370654.1	HNH endonuclease	-
FCG87_RS02750 (FCG87_002740)	572357..572824	+	468	WP_072203119.1	SymE family type I addiction module toxin	-
FCG87_RS02755 (FCG87_002745)	573041..573499	+	459	WP_045345955.1	hypothetical protein	-
FCG87_RS02760 (FCG87_002750)	573493..573825	+	333	WP_045345957.1	DUF1493 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	fosA	-	541665..578810	37145

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11998.68 Da
• Isoelectric Point: 5.5235

>T159707 WP_137048537.1 NZ_CP054411:568658-568978 [Enterobacter hormaechei]
MQISTVPATVPVSSRLSPIQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TRQEQTPFLAATDILRARRATGLINI

Nucleotide

• Length: 321 bp

>T159707 NZ_CP070111:4571412-4571747 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11936.59 Da
• Isoelectric Point: 6.4757

>AT159707 WP_137048535.1 NZ_CP054411:568303-568626 [Enterobacter hormaechei]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGAFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIAIYPQTPASQ

Nucleotide

• Length: 324 bp

>AT159707 NZ_CP070111:4571164-4571412 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA