Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3693261..3693945 Replicon chromosome
Accession NZ_CP054410
Organism Enterobacter hormaechei strain KCJ3K13

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FCG85_RS18250 Protein ID WP_216293086.1
Coordinates 3693622..3693945 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FCG85_RS18245 Protein ID WP_137041990.1
Coordinates 3693261..3693584 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCG85_RS18225 (FCG85_018220) 3688550..3691069 - 2520 WP_137041993.1 antiviral RADAR system adenosine triphosphatase RdrA -
FCG85_RS18230 (FCG85_018225) 3691688..3692506 + 819 WP_170965312.1 DUF932 domain-containing protein -
FCG85_RS18235 (FCG85_018230) 3692539..3693009 + 471 WP_137041991.1 DNA repair protein RadC -
FCG85_RS18240 (FCG85_018235) 3693018..3693239 + 222 WP_032642916.1 DUF987 domain-containing protein -
FCG85_RS18245 (FCG85_018240) 3693261..3693584 + 324 WP_137041990.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FCG85_RS18250 (FCG85_018245) 3693622..3693945 + 324 WP_216293086.1 TA system toxin CbtA family protein Toxin
FCG85_RS18255 (FCG85_018250) 3694223..3695533 - 1311 WP_022651678.1 amidase family protein -
FCG85_RS18260 (FCG85_018255) 3695587..3696882 - 1296 WP_022651679.1 histidinol dehydrogenase -
FCG85_RS18265 (FCG85_018260) 3696883..3698025 - 1143 WP_015571629.1 ester cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(10-106)

Antitoxin

Antitoxin CbeA

(4-102)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12149.88 Da        Isoelectric Point: 6.0672

>T159703 WP_216293086.1 NZ_CP054410:3693622-3693945 [Enterobacter hormaechei]
ISSVPATVPVSSRLSPVMVWQQLLTYLLEHHYGLTLNDTPFHDDTAIEEHIDAGITLADAVNFLVEKYELVRIDRKGFSW
QEQTPYISVVDILRARRSTGLLKTNVK

Download         Length: 324 bp

>T159703 NZ_CP070111:3658175-3658282 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12133.90 Da        Isoelectric Point: 5.9562

>AT159703 WP_137041990.1 NZ_CP054410:3693261-3693584 [Enterobacter hormaechei]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNEEEALCLEQAFPLVMKQLELMLTTGEMNPRHQHCVTLYHN
ELTCEADTLGSHGYVYIVIYPQAFATR

Download         Length: 324 bp

>AT159703 NZ_CP070111:c3658126-3658060 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References