Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3139977..3141760 Replicon chromosome
Accession NZ_CP054410
Organism Enterobacter hormaechei strain KCJ3K13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FCG85_RS15505 Protein ID WP_063401326.1
Coordinates 3139977..3141326 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag FCG85_RS15510 Protein ID WP_003859317.1
Coordinates 3141323..3141760 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCG85_RS15480 (FCG85_015485) 3135800..3136735 - 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -
FCG85_RS15485 (FCG85_015490) 3136904..3137299 + 396 WP_003859308.1 CidA/LrgA family protein -
FCG85_RS15490 (FCG85_015495) 3137296..3137991 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
FCG85_RS15495 (FCG85_015500) 3138120..3139004 + 885 WP_003859312.1 cytidine deaminase -
FCG85_RS15500 (FCG85_015505) 3139132..3139842 + 711 WP_003859314.1 outer membrane permeability protein SanA -
FCG85_RS15505 (FCG85_015510) 3139977..3141326 + 1350 WP_063401326.1 HipA domain-containing protein Toxin
FCG85_RS15510 (FCG85_015515) 3141323..3141760 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
FCG85_RS15515 (FCG85_015520) 3141799..3142809 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
FCG85_RS15520 (FCG85_015525) 3142825..3144345 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
FCG85_RS15525 (FCG85_015530) 3144425..3145423 - 999 WP_137041825.1 galactose/glucose ABC transporter substrate-binding protein MglB -
FCG85_RS15530 (FCG85_015535) 3145719..3146741 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51149.84 Da        Isoelectric Point: 4.6562

>T159702 WP_063401326.1 NZ_CP054410:3139977-3141326 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T159702 NZ_CP070111:3657693-3657800 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT159702 WP_003859317.1 NZ_CP054410:3141323-3141760 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT159702 NZ_CP070111:c3657636-3657578 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References