Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2246743..2247482 Replicon chromosome
Accession NZ_CP054410
Organism Enterobacter hormaechei strain KCJ3K13

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag FCG85_RS11105 Protein ID WP_003857133.1
Coordinates 2246997..2247482 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag FCG85_RS11100 Protein ID WP_045336276.1
Coordinates 2246743..2247009 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCG85_RS11080 (FCG85_011090) 2242219..2243205 + 987 WP_022651202.1 DUF979 domain-containing protein -
FCG85_RS11085 (FCG85_011095) 2243215..2244210 + 996 WP_137041787.1 DUF2891 domain-containing protein -
FCG85_RS11090 (FCG85_011100) 2244232..2245620 - 1389 WP_058658946.1 MFS transporter -
FCG85_RS11095 (FCG85_011105) 2245750..2246679 + 930 WP_060579891.1 LysR family transcriptional regulator -
FCG85_RS11100 (FCG85_011110) 2246743..2247009 + 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
FCG85_RS11105 (FCG85_011115) 2246997..2247482 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
FCG85_RS11110 (FCG85_011120) 2247660..2248952 - 1293 WP_045896810.1 glycosyl hydrolase family 28 protein -
FCG85_RS11115 (FCG85_011125) 2249057..2249815 - 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
FCG85_RS11120 (FCG85_011130) 2249902..2250486 + 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
FCG85_RS11125 (FCG85_011135) 2250571..2251329 + 759 WP_137041786.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T159693 WP_003857133.1 NZ_CP054410:2246997-2247482 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T159693 NZ_CP070111:1322845-1322952 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT159693 WP_045336276.1 NZ_CP054410:2246743-2247009 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT159693 NZ_CP070111:c1322792-1322731 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure

References