Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1084400..1085020 Replicon chromosome
Accession NZ_CP054410
Organism Enterobacter hormaechei strain KCJ3K13

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FCG85_RS05350 Protein ID WP_015571250.1
Coordinates 1084400..1084618 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FCG85_RS05355 Protein ID WP_006809850.1
Coordinates 1084646..1085020 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCG85_RS05320 (FCG85_005320) 1080412..1080672 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FCG85_RS05325 (FCG85_005325) 1080675..1080815 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FCG85_RS05330 (FCG85_005330) 1080812..1081522 - 711 WP_022650493.1 GNAT family protein -
FCG85_RS05335 (FCG85_005335) 1081624..1083084 + 1461 WP_137041838.1 PLP-dependent aminotransferase family protein -
FCG85_RS05340 (FCG85_005340) 1083056..1083523 - 468 WP_137041833.1 YlaC family protein -
FCG85_RS05345 (FCG85_005345) 1083640..1084191 - 552 WP_022650496.1 maltose O-acetyltransferase -
FCG85_RS05350 (FCG85_005350) 1084400..1084618 - 219 WP_015571250.1 HHA domain-containing protein Toxin
FCG85_RS05355 (FCG85_005355) 1084646..1085020 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FCG85_RS05360 (FCG85_005360) 1085531..1088677 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
FCG85_RS05365 (FCG85_005365) 1088700..1089893 - 1194 WP_110108173.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T159692 WP_015571250.1 NZ_CP054410:c1084618-1084400 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T159692 NZ_CP070111:c1271295-1271140 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGTTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT159692 WP_006809850.1 NZ_CP054410:c1085020-1084646 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT159692 NZ_CP070111:1271307-1271365 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References