Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4454588..4455085 Replicon chromosome
Accession NZ_CP054407
Organism Escherichia coli strain KCJ3K291

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag FR957_RS21915 Protein ID WP_001173343.1
Coordinates 4454588..4454761 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag FR957_RS21920 Protein ID WP_071988580.1
Coordinates 4454789..4455085 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR957_RS21905 (4451258) 4451258..4452715 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
FR957_RS21910 (4452952) 4452952..4454469 + 1518 WP_001295087.1 lysine--tRNA ligase -
FR957_RS21915 (4454588) 4454588..4454761 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
FR957_RS21920 (4454789) 4454789..4455085 - 297 WP_071988580.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
FR957_RS21925 (4455312) 4455312..4455584 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
FR957_RS21930 (4455797) 4455797..4459726 - 3930 WP_046201569.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4432733..4478405 45672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T159688 WP_001173343.1 NZ_CP054407:c4454761-4454588 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T159688 NZ_CP070111:579167-579322 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11482.00 Da        Isoelectric Point: 4.1705

>AT159688 WP_071988580.1 NZ_CP054407:c4455085-4454789 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSTIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT159688 NZ_CP070111:c579155-579097 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References