159687

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4329029..4329624 Replicon chromosome
Accession NZ_CP054407
Organism Escherichia coli strain KCJ3K291

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag FR957_RS21290 Protein ID WP_000239579.1
Coordinates 4329029..4329379 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2J1DIF8
Locus tag FR957_RS21295 Protein ID WP_001223209.1
Coordinates 4329373..4329624 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR957_RS21270 (4324475) 4324475..4325497 - 1023 WP_024251350.1 ABC transporter permease -
FR957_RS21275 (4325511) 4325511..4327013 - 1503 WP_000205810.1 sugar ABC transporter ATP-binding protein -
FR957_RS21280 (4327153) 4327153..4328109 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FR957_RS21285 (4328419) 4328419..4328949 + 531 WP_000055075.1 inorganic diphosphatase -
FR957_RS21290 (4329029) 4329029..4329379 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
FR957_RS21295 (4329373) 4329373..4329624 - 252 WP_001223209.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FR957_RS21300 (4329836) 4329836..4330177 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
FR957_RS21305 (4330180) 4330180..4333959 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T159687 WP_000239579.1 NZ_CP054407:c4329379-4329029 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T159687 NZ_CP070111:c575070-574783 [Escherichia coli]
ATGTTACCCATTTTGTGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCTAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGGATTGAAACGTCTGTTTTAGCCCTCTCTGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAACTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.4201

>AT159687 WP_001223209.1 NZ_CP054407:c4329624-4329373 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWSKSTPAGD
EIW

Download         Length: 252 bp

>AT159687 NZ_CP070111:c575261-575070 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTACGCGC
TAAAGTGGCGTCAAGCCTTGCAGACCCTCGTCCCTCAATTCCACATGATGAGGTAATGGCTGAAATGGAGAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J1DIF8

References