Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4564777..4565293 Replicon chromosome
Accession NZ_CP054406
Organism Klebsiella pneumoniae strain KCJ3K293

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FOH49_RS24035 Protein ID WP_004178374.1
Coordinates 4564777..4565061 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FOH49_RS24040 Protein ID WP_002886901.1
Coordinates 4565051..4565293 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOH49_RS24010 (FOH49_024055) 4560261..4560524 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
FOH49_RS24015 (FOH49_024060) 4560654..4560827 + 174 WP_032408826.1 hypothetical protein -
FOH49_RS24020 (FOH49_024065) 4560830..4561573 + 744 WP_143873029.1 MurR/RpiR family transcriptional regulator -
FOH49_RS24025 (FOH49_024070) 4561930..4564068 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FOH49_RS24030 (FOH49_024075) 4564309..4564773 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FOH49_RS24035 (FOH49_024080) 4564777..4565061 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOH49_RS24040 (FOH49_024085) 4565051..4565293 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOH49_RS24045 (FOH49_024090) 4565371..4567281 - 1911 WP_143873031.1 PRD domain-containing protein -
FOH49_RS24050 (FOH49_024095) 4567304..4568458 - 1155 WP_002886900.1 lactonase family protein -
FOH49_RS24055 (FOH49_024100) 4568525..4569265 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T159659 WP_004178374.1 NZ_CP054406:c4565061-4564777 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T159659 NZ_CP070103:c2445123-2444746 [Escherichia coli]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT159659 WP_002886901.1 NZ_CP054406:c4565293-4565051 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT159659 NZ_CP070103:c2445533-2445174 [Escherichia coli]
TTGTCGAATAAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGTCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
GGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References