Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 850548..851205 Replicon chromosome
Accession NZ_CP054406
Organism Klebsiella pneumoniae strain KCJ3K293

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FOH49_RS05885 Protein ID WP_002916310.1
Coordinates 850795..851205 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FOH49_RS05880 Protein ID WP_002916312.1
Coordinates 850548..850814 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOH49_RS05855 (FOH49_005875) 845704..847137 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
FOH49_RS05860 (FOH49_005880) 847256..847984 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FOH49_RS05865 (FOH49_005885) 848034..848345 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
FOH49_RS05870 (FOH49_005890) 848509..849168 + 660 WP_002916317.1 hemolysin III family protein -
FOH49_RS05875 (FOH49_005895) 849319..850302 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FOH49_RS05880 (FOH49_005900) 850548..850814 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FOH49_RS05885 (FOH49_005905) 850795..851205 + 411 WP_002916310.1 protein YgfX Toxin
FOH49_RS05890 (FOH49_005910) 851212..851733 - 522 WP_004144730.1 flavodoxin FldB -
FOH49_RS05895 (FOH49_005915) 851834..852730 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FOH49_RS05900 (FOH49_005920) 852753..853466 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOH49_RS05905 (FOH49_005925) 853472..855205 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T159646 WP_002916310.1 NZ_CP054406:850795-851205 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T159646 NZ_CP070102:1564018-1564269 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT159646 WP_002916312.1 NZ_CP054406:850548-850814 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT159646 NZ_CP070102:1564272-1564673 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References