Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3874583..3875202 Replicon chromosome
Accession NZ_CP054403
Organism Klebsiella pneumoniae strain KCJ3K292

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FOH48_RS20800 Protein ID WP_002892050.1
Coordinates 3874984..3875202 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FOH48_RS20795 Protein ID WP_002892066.1
Coordinates 3874583..3874957 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOH48_RS20785 (FOH48_020715) 3869735..3870928 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FOH48_RS20790 (FOH48_020720) 3870951..3874097 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FOH48_RS20795 (FOH48_020725) 3874583..3874957 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FOH48_RS20800 (FOH48_020730) 3874984..3875202 + 219 WP_002892050.1 HHA domain-containing protein Toxin
FOH48_RS20805 (FOH48_020735) 3875361..3875927 + 567 WP_002892030.1 maltose O-acetyltransferase -
FOH48_RS20810 (FOH48_020740) 3875899..3876039 - 141 WP_004147370.1 hypothetical protein -
FOH48_RS20815 (FOH48_020745) 3876060..3876530 + 471 WP_002892026.1 YlaC family protein -
FOH48_RS20820 (FOH48_020750) 3876505..3877956 - 1452 WP_021313732.1 PLP-dependent aminotransferase family protein -
FOH48_RS20825 (FOH48_020755) 3878057..3878755 + 699 WP_002892021.1 GNAT family protein -
FOH48_RS20830 (FOH48_020760) 3878752..3878892 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FOH48_RS20835 (FOH48_020765) 3878892..3879155 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T159635 WP_002892050.1 NZ_CP054403:3874984-3875202 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T159635 NZ_CP070098:c4014794-4014687 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT159635 WP_002892066.1 NZ_CP054403:3874583-3874957 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT159635 NZ_CP070098:4014842-4014908 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References