Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 776722..777500 Replicon chromosome
Accession NZ_CP054403
Organism Klebsiella pneumoniae strain KCJ3K292

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag FOH48_RS05560 Protein ID WP_031591140.1
Coordinates 777012..777500 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag FOH48_RS05555 Protein ID WP_004150912.1
Coordinates 776722..777015 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOH48_RS05535 (FOH48_005505) 771930..772532 - 603 WP_004174410.1 short chain dehydrogenase -
FOH48_RS05540 (FOH48_005510) 772630..773541 + 912 WP_004181308.1 LysR family transcriptional regulator -
FOH48_RS05545 (FOH48_005515) 773542..774690 - 1149 WP_004174416.1 PLP-dependent aspartate aminotransferase family protein -
FOH48_RS05550 (FOH48_005520) 774701..776077 - 1377 WP_004217775.1 cystathionine beta-synthase -
FOH48_RS05555 (FOH48_005525) 776722..777015 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
FOH48_RS05560 (FOH48_005530) 777012..777500 + 489 WP_031591140.1 GNAT family N-acetyltransferase Toxin
FOH48_RS05565 (FOH48_005535) 777581..781324 - 3744 WP_144296106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17604.53 Da        Isoelectric Point: 7.7754

>T159623 WP_031591140.1 NZ_CP054403:777012-777500 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCGSDSNVLAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T159623 NZ_CP070098:c1251273-1251166 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT159623 WP_004150912.1 NZ_CP054403:776722-777015 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT159623 NZ_CP070098:1251326-1251387 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References