Detailed information of TA system TA159611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2550119..2551707
• Replicon: chromosome
• Accession: NZ_CP054400
• Organism: Klebsiella pneumoniae strain KCJ3K307

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FOH51_RS14175
• Protein ID: WP_143873367.1
• Coordinates: 2550119..2551441 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: FOH51_RS14180
• Protein ID: WP_002904790.1
• Coordinates: 2551441..2551707 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOH51_RS14160 (FOH51_014150)	2545184..2547685	+	2502	WP_143873369.1	fimbria/pilus outer membrane usher protein	-
FOH51_RS14165 (FOH51_014155)	2547673..2548677	+	1005	WP_023286423.1	fimbrial protein	-
FOH51_RS14170 (FOH51_014160)	2548810..2550102	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
FOH51_RS14175 (FOH51_014165)	2550119..2551441	-	1323	WP_143873367.1	type II toxin-antitoxin system HipA family toxin	Toxin
FOH51_RS14180 (FOH51_014170)	2551441..2551707	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
FOH51_RS14185 (FOH51_014175)	2551972..2552298	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
FOH51_RS14190 (FOH51_014180)	2552295..2552795	-	501	WP_023286422.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
FOH51_RS14195 (FOH51_014185)	2552773..2554152	-	1380	WP_004199850.1	nucleobase:cation symporter-2 family protein	-
FOH51_RS14200 (FOH51_014190)	2554498..2555652	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
FOH51_RS14205 (FOH51_014195)	2555633..2556556	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49116.38 Da
• Isoelectric Point: 7.2487

>T159611 WP_143873367.1 NZ_CP054400:c2551441-2550119 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDTPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T159611 NZ_CP070092:1960321-1960854 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT159611 WP_002904790.1 NZ_CP054400:c2551707-2551441 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT159611 NZ_CP070092:1960044-1960310 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8